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Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer

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Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer. / Jayne, D. G.; Heath, R. M.; Dewhurst, O. et al.
In: European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Vol. 28, No. 1, 02.2002, p. 30-36.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Jayne, DG, Heath, RM, Dewhurst, O, Scott, N & Guillou, PJ 2002, 'Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer', European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 28, no. 1, pp. 30-36. https://doi.org/10.1053/ejso.2001.1182

APA

Jayne, D. G., Heath, R. M., Dewhurst, O., Scott, N., & Guillou, P. J. (2002). Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer. European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 28(1), 30-36. https://doi.org/10.1053/ejso.2001.1182

Vancouver

Jayne DG, Heath RM, Dewhurst O, Scott N, Guillou PJ. Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer. European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2002 Feb;28(1):30-36. doi: 10.1053/ejso.2001.1182

Author

Jayne, D. G. ; Heath, R. M. ; Dewhurst, O. et al. / Extracellular matrix proteins and chemoradiotherapy : alpha5beta1 integrin as a predictive marker in rectal cancer. In: European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2002 ; Vol. 28, No. 1. pp. 30-36.

Bibtex

@article{e52d570695624f2184b13ffe7d577b07,
title = "Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer",
abstract = "AIMS: To investigate the effects of extracellular matrix (ECM) protein expression on the rates of apoptosis and proliferation in rectal cancers and subsequent response to chemoradiotherapy (CRT).METHODS: The expression of fibronectin, collagen IV, laminin and the fibronectin receptor (FnR, alpha5beta1 integrin) were analysed in 32 pre-treatment rectal cancer biopsies by immunohistochemistry. ECM expression was correlated with tumour mitotic index (MI), apoptotic index (AI) and histopathological response to CRT.RESULTS: 18/32 cancers showed a poor response and 14/32 a good response (5/14 with complete pathological response) to CRT. Moderate to strong staining was seen in 22/32 cancers for fibronectin, 5/32 for collagen IV and 18/32 for laminin. Tumour FnR was related to stromal fibronectin content, and was significantly associated with CRT response; good responders having higher FnR expression compared to poor responders. No association was found between FnR expression and either MI or AI in pre-treatment biopsies, nor between MI or AI and CRT response.CONCLUSIONS: Tumour FnR expression is independent of MI and AI, and may serve as a useful marker for CRT response in rectal cancer.",
keywords = "Apoptosis, Collagen Type IV, Combined Modality Therapy, Extracellular Matrix Proteins, Fibronectins, Humans, Immunohistochemistry, Laminin, Mitotic Index, Receptors, Fibronectin, Rectal Neoplasms",
author = "Jayne, {D. G.} and Heath, {R. M.} and O. Dewhurst and N. Scott and Guillou, {P. J.}",
note = "Copyright Harcourt Publishers Limited.",
year = "2002",
month = feb,
doi = "10.1053/ejso.2001.1182",
language = "English",
volume = "28",
pages = "30--36",
journal = "European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology",
issn = "0748-7983",
publisher = "W.B. Saunders Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Extracellular matrix proteins and chemoradiotherapy

T2 - alpha5beta1 integrin as a predictive marker in rectal cancer

AU - Jayne, D. G.

AU - Heath, R. M.

AU - Dewhurst, O.

AU - Scott, N.

AU - Guillou, P. J.

N1 - Copyright Harcourt Publishers Limited.

PY - 2002/2

Y1 - 2002/2

N2 - AIMS: To investigate the effects of extracellular matrix (ECM) protein expression on the rates of apoptosis and proliferation in rectal cancers and subsequent response to chemoradiotherapy (CRT).METHODS: The expression of fibronectin, collagen IV, laminin and the fibronectin receptor (FnR, alpha5beta1 integrin) were analysed in 32 pre-treatment rectal cancer biopsies by immunohistochemistry. ECM expression was correlated with tumour mitotic index (MI), apoptotic index (AI) and histopathological response to CRT.RESULTS: 18/32 cancers showed a poor response and 14/32 a good response (5/14 with complete pathological response) to CRT. Moderate to strong staining was seen in 22/32 cancers for fibronectin, 5/32 for collagen IV and 18/32 for laminin. Tumour FnR was related to stromal fibronectin content, and was significantly associated with CRT response; good responders having higher FnR expression compared to poor responders. No association was found between FnR expression and either MI or AI in pre-treatment biopsies, nor between MI or AI and CRT response.CONCLUSIONS: Tumour FnR expression is independent of MI and AI, and may serve as a useful marker for CRT response in rectal cancer.

AB - AIMS: To investigate the effects of extracellular matrix (ECM) protein expression on the rates of apoptosis and proliferation in rectal cancers and subsequent response to chemoradiotherapy (CRT).METHODS: The expression of fibronectin, collagen IV, laminin and the fibronectin receptor (FnR, alpha5beta1 integrin) were analysed in 32 pre-treatment rectal cancer biopsies by immunohistochemistry. ECM expression was correlated with tumour mitotic index (MI), apoptotic index (AI) and histopathological response to CRT.RESULTS: 18/32 cancers showed a poor response and 14/32 a good response (5/14 with complete pathological response) to CRT. Moderate to strong staining was seen in 22/32 cancers for fibronectin, 5/32 for collagen IV and 18/32 for laminin. Tumour FnR was related to stromal fibronectin content, and was significantly associated with CRT response; good responders having higher FnR expression compared to poor responders. No association was found between FnR expression and either MI or AI in pre-treatment biopsies, nor between MI or AI and CRT response.CONCLUSIONS: Tumour FnR expression is independent of MI and AI, and may serve as a useful marker for CRT response in rectal cancer.

KW - Apoptosis

KW - Collagen Type IV

KW - Combined Modality Therapy

KW - Extracellular Matrix Proteins

KW - Fibronectins

KW - Humans

KW - Immunohistochemistry

KW - Laminin

KW - Mitotic Index

KW - Receptors, Fibronectin

KW - Rectal Neoplasms

U2 - 10.1053/ejso.2001.1182

DO - 10.1053/ejso.2001.1182

M3 - Journal article

C2 - 11869010

VL - 28

SP - 30

EP - 36

JO - European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

JF - European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

SN - 0748-7983

IS - 1

ER -