TY - JOUR

T1 - Extracting biomarkers of commitment to cancer development

T2 - potential role of vibrational spectroscopy in systems biology

AU - Theophilou, Georgios

AU - Paraskevaidi, Maria

AU - Gomes De Lima, Kassio Michell

AU - Kyrgiou, Maria

AU - Martin-Hirsch, Pierre Leonard

AU - Martin, Francis Luke

PY - 2015/5/4

Y1 - 2015/5/4

N2 - The complex processes driving cancer have so far impeded the discovery of dichotomous biomarkers associated with its initiation and progression. Reductionist approaches utilizing ‘omics’ technologies have met some success in identifying molecular alterations associated with carcinogenesis. Systems biology is an emerging science that combines high-throughput investigation techniques to define the dynamic interplay between regulatory biological systems in response to internal and external cues. Vibrational spectroscopy has the potential to play an integral role within systems biology research approaches. It is capable of examining global models of carcinogenesis by scrutinizing chemical bond alterations within molecules. The application of infrared or Raman spectroscopic approaches coupled with computational analysis under the systems biology umbrella can assist the transition of biomarker research from the molecular level to the system level. The comprehensive representation of carcinogenesis as a multilevel biological process will inevitably revolutionize cancer-related healthcare by personalizing risk prediction and prevention.

AB - The complex processes driving cancer have so far impeded the discovery of dichotomous biomarkers associated with its initiation and progression. Reductionist approaches utilizing ‘omics’ technologies have met some success in identifying molecular alterations associated with carcinogenesis. Systems biology is an emerging science that combines high-throughput investigation techniques to define the dynamic interplay between regulatory biological systems in response to internal and external cues. Vibrational spectroscopy has the potential to play an integral role within systems biology research approaches. It is capable of examining global models of carcinogenesis by scrutinizing chemical bond alterations within molecules. The application of infrared or Raman spectroscopic approaches coupled with computational analysis under the systems biology umbrella can assist the transition of biomarker research from the molecular level to the system level. The comprehensive representation of carcinogenesis as a multilevel biological process will inevitably revolutionize cancer-related healthcare by personalizing risk prediction and prevention.

KW - carcinogenesis

KW - computational techniques for data fusion

KW - omics technologies

KW - screening biomarkers

KW - systems biology

KW - vibrational spectroscopy

U2 - 10.1586/14737159.2015.1028372

DO - 10.1586/14737159.2015.1028372

M3 - Journal article

VL - 15

SP - 693

EP - 713

JO - Expert Review of Molecular Diagnostics

JF - Expert Review of Molecular Diagnostics

SN - 1473-7159

IS - 5

ER -