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Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment. / Polden, Megan; Crawford, Trevor.
In: Vision, Vol. 7, No. 2, 38, 01.05.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Polden, M & Crawford, T 2023, 'Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment', Vision, vol. 7, no. 2, 38. https://doi.org/10.3390/vision7020038

APA

Polden, M., & Crawford, T. (2023). Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment. Vision, 7(2), Article 38. https://doi.org/10.3390/vision7020038

Vancouver

Polden M, Crawford T. Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment. Vision. 2023 May 1;7(2):38. doi: 10.3390/vision7020038

Author

Polden, Megan ; Crawford, Trevor. / Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment : An Eye Tracking Study of Cognitive Impairment. In: Vision. 2023 ; Vol. 7, No. 2.

Bibtex

@article{77d157b430624a4f8bf5403a1d98ffc1,
title = "Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment",
abstract = "Studies demonstrated impairment in the control of saccadic eye movements in Alzheimer{\textquoteright}s disease (AD) and people with mild cognitive impairment (MCI) when conducting the pro-saccade and antisaccade tasks. Research showed that changes in the pro and antisaccade latencies may be particularly sensitive to dementia and general executive functioning. These tasks show potential for diagnostic use, as they provide a rich set of potential eye tracking markers. One such marker, the coefficient of variation (CV), is so far overlooked. For biological markers to be reliable, they must be able to detect abnormalities in preclinical stages. MCI is often viewed as a predecessor to AD, with certain classifications of MCI more likely than others to progress to AD. The current study examined the potential of CV scores on pro and antisaccade tasks to distinguish participants with AD, amnestic MCI (aMCI), non-amnesiac MCI (naMCI), and older controls. The analyses revealed no significant differences in CV scores across the groups using the pro or antisaccade task. Antisaccade mean latencies were able to distinguish participants with AD and the MCI subgroups. Future research is needed on CV measures and attentional fluctuations in AD and MCI individuals to fully assess this measure{\textquoteright}s potential to robustly distinguish clinical groups with high sensitivity and specificity.",
author = "Megan Polden and Trevor Crawford",
year = "2023",
month = may,
day = "1",
doi = "10.3390/vision7020038",
language = "English",
volume = "7",
journal = "Vision",
number = "2",

}

RIS

TY - JOUR

T1 - Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment

T2 - An Eye Tracking Study of Cognitive Impairment

AU - Polden, Megan

AU - Crawford, Trevor

PY - 2023/5/1

Y1 - 2023/5/1

N2 - Studies demonstrated impairment in the control of saccadic eye movements in Alzheimer’s disease (AD) and people with mild cognitive impairment (MCI) when conducting the pro-saccade and antisaccade tasks. Research showed that changes in the pro and antisaccade latencies may be particularly sensitive to dementia and general executive functioning. These tasks show potential for diagnostic use, as they provide a rich set of potential eye tracking markers. One such marker, the coefficient of variation (CV), is so far overlooked. For biological markers to be reliable, they must be able to detect abnormalities in preclinical stages. MCI is often viewed as a predecessor to AD, with certain classifications of MCI more likely than others to progress to AD. The current study examined the potential of CV scores on pro and antisaccade tasks to distinguish participants with AD, amnestic MCI (aMCI), non-amnesiac MCI (naMCI), and older controls. The analyses revealed no significant differences in CV scores across the groups using the pro or antisaccade task. Antisaccade mean latencies were able to distinguish participants with AD and the MCI subgroups. Future research is needed on CV measures and attentional fluctuations in AD and MCI individuals to fully assess this measure’s potential to robustly distinguish clinical groups with high sensitivity and specificity.

AB - Studies demonstrated impairment in the control of saccadic eye movements in Alzheimer’s disease (AD) and people with mild cognitive impairment (MCI) when conducting the pro-saccade and antisaccade tasks. Research showed that changes in the pro and antisaccade latencies may be particularly sensitive to dementia and general executive functioning. These tasks show potential for diagnostic use, as they provide a rich set of potential eye tracking markers. One such marker, the coefficient of variation (CV), is so far overlooked. For biological markers to be reliable, they must be able to detect abnormalities in preclinical stages. MCI is often viewed as a predecessor to AD, with certain classifications of MCI more likely than others to progress to AD. The current study examined the potential of CV scores on pro and antisaccade tasks to distinguish participants with AD, amnestic MCI (aMCI), non-amnesiac MCI (naMCI), and older controls. The analyses revealed no significant differences in CV scores across the groups using the pro or antisaccade task. Antisaccade mean latencies were able to distinguish participants with AD and the MCI subgroups. Future research is needed on CV measures and attentional fluctuations in AD and MCI individuals to fully assess this measure’s potential to robustly distinguish clinical groups with high sensitivity and specificity.

U2 - 10.3390/vision7020038

DO - 10.3390/vision7020038

M3 - Journal article

C2 - 37218956

VL - 7

JO - Vision

JF - Vision

IS - 2

M1 - 38

ER -