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Facile Photochemical Modification of Silk Protein–Based Biomaterials

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Facile Photochemical Modification of Silk Protein–Based Biomaterials. / Hardy, John George; Bertin, Annabelle; Torres-Rendon, Jose Guillermo et al.

In: Macromolecular Bioscience , Vol. 18, No. 11, 1800216, 01.11.2018.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Hardy, JG, Bertin, A, Torres-Rendon, JG, Leal-Egana, A, Humenik, M, Bauer, F, Walther, A, Cölfen, H, Schlaad, H & Scheibel, TR 2018, 'Facile Photochemical Modification of Silk Protein–Based Biomaterials', Macromolecular Bioscience , vol. 18, no. 11, 1800216. https://doi.org/10.1002/mabi.201800216

APA

Hardy, J. G., Bertin, A., Torres-Rendon, J. G., Leal-Egana, A., Humenik, M., Bauer, F., Walther, A., Cölfen, H., Schlaad, H., & Scheibel, T. R. (2018). Facile Photochemical Modification of Silk Protein–Based Biomaterials. Macromolecular Bioscience , 18(11), [1800216]. https://doi.org/10.1002/mabi.201800216

Vancouver

Hardy JG, Bertin A, Torres-Rendon JG, Leal-Egana A, Humenik M, Bauer F et al. Facile Photochemical Modification of Silk Protein–Based Biomaterials. Macromolecular Bioscience . 2018 Nov 1;18(11):1800216. Epub 2018 Sep 19. doi: 10.1002/mabi.201800216

Author

Hardy, John George ; Bertin, Annabelle ; Torres-Rendon, Jose Guillermo et al. / Facile Photochemical Modification of Silk Protein–Based Biomaterials. In: Macromolecular Bioscience . 2018 ; Vol. 18, No. 11.

Bibtex

@article{5f7b5a0c0b80431fb3168cdaa896217b,
title = "Facile Photochemical Modification of Silk Protein–Based Biomaterials",
abstract = "Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk‐based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer‐modified silks are mineralized. The PAA‐ and PMAA‐functionalized silks are mineralized with calcium carbonate, whereas the PAAm‐functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations. ",
keywords = "biomaterials, photochemistry, chemistry, materials science, tissue scaffold, Biomedical Engineering",
author = "Hardy, {John George} and Annabelle Bertin and Torres-Rendon, {Jose Guillermo} and Aldo Leal-Egana and Martin Humenik and Felix Bauer and Andreas Walther and Helmut C{\"o}lfen and Helmut Schlaad and Scheibel, {Thomas Rainer}",
year = "2018",
month = nov,
day = "1",
doi = "10.1002/mabi.201800216",
language = "English",
volume = "18",
journal = "Macromolecular Bioscience ",
issn = "1616-5187",
publisher = "Wiley-VCH Verlag",
number = "11",

}

RIS

TY - JOUR

T1 - Facile Photochemical Modification of Silk Protein–Based Biomaterials

AU - Hardy, John George

AU - Bertin, Annabelle

AU - Torres-Rendon, Jose Guillermo

AU - Leal-Egana, Aldo

AU - Humenik, Martin

AU - Bauer, Felix

AU - Walther, Andreas

AU - Cölfen, Helmut

AU - Schlaad, Helmut

AU - Scheibel, Thomas Rainer

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk‐based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer‐modified silks are mineralized. The PAA‐ and PMAA‐functionalized silks are mineralized with calcium carbonate, whereas the PAAm‐functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations.

AB - Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk‐based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer‐modified silks are mineralized. The PAA‐ and PMAA‐functionalized silks are mineralized with calcium carbonate, whereas the PAAm‐functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations.

KW - biomaterials

KW - photochemistry

KW - chemistry

KW - materials science

KW - tissue scaffold

KW - Biomedical Engineering

U2 - 10.1002/mabi.201800216

DO - 10.1002/mabi.201800216

M3 - Journal article

VL - 18

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

SN - 1616-5187

IS - 11

M1 - 1800216

ER -