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Familial recurrent hydatidiform mole: a review

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Familial recurrent hydatidiform mole: a review. / Fisher, Rosemary A.; Hodges, Matt; Newlands, Edward S.
In: Journal of Reproductive Medicine, Vol. 49, No. 8, 08.2004, p. 595-601.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Fisher, RA, Hodges, M & Newlands, ES 2004, 'Familial recurrent hydatidiform mole: a review', Journal of Reproductive Medicine, vol. 49, no. 8, pp. 595-601. <http://www.reproductivemedicine.com/toc/auto_abstract.php?id=21703>

APA

Fisher, R. A., Hodges, M., & Newlands, E. S. (2004). Familial recurrent hydatidiform mole: a review. Journal of Reproductive Medicine, 49(8), 595-601. http://www.reproductivemedicine.com/toc/auto_abstract.php?id=21703

Vancouver

Fisher RA, Hodges M, Newlands ES. Familial recurrent hydatidiform mole: a review. Journal of Reproductive Medicine. 2004 Aug;49(8):595-601.

Author

Fisher, Rosemary A. ; Hodges, Matt ; Newlands, Edward S. / Familial recurrent hydatidiform mole : a review. In: Journal of Reproductive Medicine. 2004 ; Vol. 49, No. 8. pp. 595-601.

Bibtex

@article{f60e8d31f7014d1190e094b4993a0070,
title = "Familial recurrent hydatidiform mole: a review",
abstract = "This article reviews published data on familial recurrent hydatidiform mole with particular reference to the genetic basis of this condition, the likely outcome of subsequent pregnancies in affected women and the risk of persistent trophoblastic disease following molar pregnancies in these families. Familial recurrent hydatidiform mole is characterized by recurrent complete hydatidiform moles of biparental, rather than the more usual androgenetic, origin. Although the specific gene defect in these families has not been identified, genetic mapping has shown that in most families the gene responsible is located in a 1.1 Mb region on chromosome 19q13.4. Mutations in this gene result in dysregulation of imprinting in the female germ line with abnormal development of both embryonic and extraembryonic tissue. Subsequent pregnancies in women diagnosed with this condition are likely to be complete hydatidiform moles. In 152 pregnancies in affected women, 113 (74%) were complete hydatidiform moles, 26 (17%) were miscarriages, 6 (4%) were partial hydatidiform moles, and 7 (5%) were normal pregnancies. Molar pregnancies in women with familial recurrent hydatidiform mole have a risk of progressing to persis-tent trophoblastic disease similar to that of androgenetic complete hydatidiform mole. ",
keywords = "Hydatidiform mole, pregnancy, molar, familial recurrent hydatidiform mole",
author = "Fisher, {Rosemary A.} and Matt Hodges and Newlands, {Edward S.}",
year = "2004",
month = aug,
language = "English",
volume = "49",
pages = "595--601",
journal = "Journal of Reproductive Medicine",
publisher = "Donna Kessel",
number = "8",

}

RIS

TY - JOUR

T1 - Familial recurrent hydatidiform mole

T2 - a review

AU - Fisher, Rosemary A.

AU - Hodges, Matt

AU - Newlands, Edward S.

PY - 2004/8

Y1 - 2004/8

N2 - This article reviews published data on familial recurrent hydatidiform mole with particular reference to the genetic basis of this condition, the likely outcome of subsequent pregnancies in affected women and the risk of persistent trophoblastic disease following molar pregnancies in these families. Familial recurrent hydatidiform mole is characterized by recurrent complete hydatidiform moles of biparental, rather than the more usual androgenetic, origin. Although the specific gene defect in these families has not been identified, genetic mapping has shown that in most families the gene responsible is located in a 1.1 Mb region on chromosome 19q13.4. Mutations in this gene result in dysregulation of imprinting in the female germ line with abnormal development of both embryonic and extraembryonic tissue. Subsequent pregnancies in women diagnosed with this condition are likely to be complete hydatidiform moles. In 152 pregnancies in affected women, 113 (74%) were complete hydatidiform moles, 26 (17%) were miscarriages, 6 (4%) were partial hydatidiform moles, and 7 (5%) were normal pregnancies. Molar pregnancies in women with familial recurrent hydatidiform mole have a risk of progressing to persis-tent trophoblastic disease similar to that of androgenetic complete hydatidiform mole.

AB - This article reviews published data on familial recurrent hydatidiform mole with particular reference to the genetic basis of this condition, the likely outcome of subsequent pregnancies in affected women and the risk of persistent trophoblastic disease following molar pregnancies in these families. Familial recurrent hydatidiform mole is characterized by recurrent complete hydatidiform moles of biparental, rather than the more usual androgenetic, origin. Although the specific gene defect in these families has not been identified, genetic mapping has shown that in most families the gene responsible is located in a 1.1 Mb region on chromosome 19q13.4. Mutations in this gene result in dysregulation of imprinting in the female germ line with abnormal development of both embryonic and extraembryonic tissue. Subsequent pregnancies in women diagnosed with this condition are likely to be complete hydatidiform moles. In 152 pregnancies in affected women, 113 (74%) were complete hydatidiform moles, 26 (17%) were miscarriages, 6 (4%) were partial hydatidiform moles, and 7 (5%) were normal pregnancies. Molar pregnancies in women with familial recurrent hydatidiform mole have a risk of progressing to persis-tent trophoblastic disease similar to that of androgenetic complete hydatidiform mole.

KW - Hydatidiform mole

KW - pregnancy

KW - molar

KW - familial recurrent hydatidiform mole

M3 - Journal article

VL - 49

SP - 595

EP - 601

JO - Journal of Reproductive Medicine

JF - Journal of Reproductive Medicine

IS - 8

ER -