Design impacts everyday life, shaping the way we engage with the world and those around us, humans and non-humans. This introductory essay presents the notion of flourishing as a springboard for different perspectives and practices. Coupled with the role of design in shaping a better world for everyone and everything, it seeks to query what the implications might mean if we are to flourish by design. Design research can be a valuable way to explore unchartered territory and revel in uncertain ground. By providing overviews of the three sections of the book, the essay sets out core themes for how we are in the world as well as how we might want to be. Design has power. It can allow us to question prevailing approaches and inspire new ones and to investigate why it enables us to radically rethink what design can do, when, and for whom.