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Fourier transform Raman spectroscopic studies of human bone

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>1/09/1994
<mark>Journal</mark>Journal of Materials Science: Materials in Medicine
Issue number9-10
Number of pages4
Pages (from-to)775-778
Publication StatusPublished
<mark>Original language</mark>English


We have concluded preliminary investigations concerning the composition of human cortical bone tissue, and of a number of samples of synthetic hydroxyapatite, using Fourier transform Raman (FT-Raman) spectroscopy. Deproteination procedures to remove the bulk of the collagen present in the tissue have allowed isolation of the mineral phase, and a comparison of the spectra obtained from the latter with those of synthetic hydroxyapatites has highlighted a number of discrepancies. FT-Raman spectra obtained for whole, wet bone samples have produced a degree of spectral detail that is much improved upon that available from existing studies. This has mainly been achieved by the successful elimination of fluorescence from the tissue, a problem which has dogged the Raman analysis of bone in particular. © 1994 Chapman & Hall.