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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. / Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P. et al.
In: Nature Genetics, Vol. 49, 20.02.2017, p. 403-415.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Warren, HR, Evangelou, E, Cabrera, CP, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, JP, Kraja, AT, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Lepe, MPS, O'Reilly, PF, Knight, J, Snieder, H, Kato, N, He, J, Tai, ES, Said, MA, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, RT, Padmanabhan, S, Mägi, R, Stanton, A, Connell, J, Bakker, SJL, Metspalu, A, Shields, DC, Thom, S, Brown, M, Sever, P, Esko, T, Hayward, C, van der Harst, P, Saleheen, D, Chowdhury, R, Chambers, JC, Chasman, DI, Chakravarti, A, Newton-Cheh, C, Lindgren, CM, Levy, D & International Consortium of Blood Pressure (ICBP) 1000G Analyses 2017, 'Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk', Nature Genetics, vol. 49, pp. 403-415. https://doi.org/10.1038/ng.3768

APA

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J., ... International Consortium of Blood Pressure (ICBP) 1000G Analyses (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 49, 403-415. https://doi.org/10.1038/ng.3768

Vancouver

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics. 2017 Feb 20;49:403-415. Epub 2017 Jan 30. doi: 10.1038/ng.3768

Author

Warren, Helen R. ; Evangelou, Evangelos ; Cabrera, Claudia P. et al. / Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. In: Nature Genetics. 2017 ; Vol. 49. pp. 403-415.

Bibtex

@article{ef5afb6e0e1a4599ae577a339f265245,
title = "Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk",
abstract = "Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.",
author = "Warren, {Helen R.} and Evangelos Evangelou and Cabrera, {Claudia P.} and He Gao and Meixia Ren and Borbala Mifsud and Ioanna Ntalla and Praveen Surendran and Chunyu Liu and Cook, {James P.} and Kraja, {Aldi T.} and Fotios Drenos and Marie Loh and Niek Verweij and Jonathan Marten and Ibrahim Karaman and Lepe, {Marcelo P. Segura} and O'Reilly, {Paul F.} and Joanne Knight and Harold Snieder and Norihiro Kato and Jiang He and Tai, {E. Shyong} and Said, {M. Abdullah} and David Porteous and Maris Alver and Neil Poulter and Martin Farrall and Gansevoort, {Ron T.} and Sandosh Padmanabhan and Reedik M{\"a}gi and Alice Stanton and John Connell and Bakker, {Stephan J. L.} and Andres Metspalu and Shields, {Denis C.} and Simon Thom and Morris Brown and Peter Sever and T{\~o}nu Esko and Caroline Hayward and {van der Harst}, Pim and Danish Saleheen and Rajiv Chowdhury and Chambers, {John C.} and Chasman, {Daniel I.} and Aravinda Chakravarti and Christopher Newton-Cheh and Lindgren, {Cecilia M.} and Daniel Levy and {International Consortium of Blood Pressure (ICBP) 1000G Analyses}",
note = "{\textcopyright} 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",
year = "2017",
month = feb,
day = "20",
doi = "10.1038/ng.3768",
language = "English",
volume = "49",
pages = "403--415",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

AU - Warren, Helen R.

AU - Evangelou, Evangelos

AU - Cabrera, Claudia P.

AU - Gao, He

AU - Ren, Meixia

AU - Mifsud, Borbala

AU - Ntalla, Ioanna

AU - Surendran, Praveen

AU - Liu, Chunyu

AU - Cook, James P.

AU - Kraja, Aldi T.

AU - Drenos, Fotios

AU - Loh, Marie

AU - Verweij, Niek

AU - Marten, Jonathan

AU - Karaman, Ibrahim

AU - Lepe, Marcelo P. Segura

AU - O'Reilly, Paul F.

AU - Knight, Joanne

AU - Snieder, Harold

AU - Kato, Norihiro

AU - He, Jiang

AU - Tai, E. Shyong

AU - Said, M. Abdullah

AU - Porteous, David

AU - Alver, Maris

AU - Poulter, Neil

AU - Farrall, Martin

AU - Gansevoort, Ron T.

AU - Padmanabhan, Sandosh

AU - Mägi, Reedik

AU - Stanton, Alice

AU - Connell, John

AU - Bakker, Stephan J. L.

AU - Metspalu, Andres

AU - Shields, Denis C.

AU - Thom, Simon

AU - Brown, Morris

AU - Sever, Peter

AU - Esko, Tõnu

AU - Hayward, Caroline

AU - van der Harst, Pim

AU - Saleheen, Danish

AU - Chowdhury, Rajiv

AU - Chambers, John C.

AU - Chasman, Daniel I.

AU - Chakravarti, Aravinda

AU - Newton-Cheh, Christopher

AU - Lindgren, Cecilia M.

AU - Levy, Daniel

AU - International Consortium of Blood Pressure (ICBP) 1000G Analyses

N1 - © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

PY - 2017/2/20

Y1 - 2017/2/20

N2 - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

AB - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

U2 - 10.1038/ng.3768

DO - 10.1038/ng.3768

M3 - Journal article

C2 - 28135244

VL - 49

SP - 403

EP - 415

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -