Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium
AU - Witt, S H
AU - Streit, F
AU - Jungkunz, M
AU - Frank, J
AU - Awasthi, S
AU - Reinbold, C S
AU - Treutlein, J
AU - Degenhardt, F
AU - Forstner, A J
AU - Heilmann-Heimbach, S
AU - Dietl, L
AU - Schwarze, C E
AU - Schendel, D
AU - Strohmaier, J
AU - Abdellaoui, A
AU - Adolfsson, R
AU - Air, T M
AU - Akil, H
AU - Alda, M
AU - Alliey-Rodriguez, N
AU - Andreassen, O A
AU - Babadjanova, G
AU - Bass, N J
AU - Bauer, M
AU - Baune, B T
AU - Bellivier, F
AU - Bergen, S
AU - Bethell, A
AU - Biernacka, J M
AU - Blackwood, D H R
AU - Boks, M P
AU - Boomsma, D I
AU - Børglum, A D
AU - Borrmann-Hassenbach, M
AU - Brennan, P
AU - Budde, M
AU - Buttenschøn, H N
AU - Byrne, E M
AU - Cervantes, P
AU - Clarke, T-K
AU - Craddock, N
AU - Cruceanu, C
AU - Curtis, D
AU - Jones, I
AU - Jones, L A
AU - McIntosh, A M
AU - Scott, L
AU - Vincent, J B
AU - Witt, C C
AU - Knight, Jo
AU - Bipolar Disorders Working Group of the Psychiatric Genomics Consortium
PY - 2017/6/20
Y1 - 2017/6/20
N2 - Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.
AB - Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.
KW - Adolescent
KW - Adult
KW - Aged
KW - Bipolar Disorder
KW - Borderline Personality Disorder
KW - Case-Control Studies
KW - Depressive Disorder, Major
KW - Female
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Genotype
KW - Humans
KW - Male
KW - Middle Aged
KW - Multifactorial Inheritance
KW - Schizophrenia
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1038/tp.2017.115
DO - 10.1038/tp.2017.115
M3 - Journal article
C2 - 28632202
VL - 7
JO - Translational Psychiatry
JF - Translational Psychiatry
SN - 2158-3188
IS - 6
M1 - e1155
ER -