Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Genomic analysis of two phlebotomine sand fly vectors of leishmania from the new and old World
AU - Sandflies
AU - Labbé, Frédéric
AU - Abdeladhim, Maha
AU - Abrudan, Jenica
AU - Araki, Alejandra Saori
AU - Araujo, Ricardo N
AU - Arensburger, Peter
AU - Benoit, Joshua B
AU - Brazil, Reginaldo Pecanha
AU - Bruno, Rafaela V
AU - Bueno da Silva Rivas, Gustavo
AU - Carvalho de Abreu, Vinicius
AU - Charamis, Jason
AU - Coutinho-Abreu, Iliano V
AU - da Costa-Latgé, Samara G
AU - Darby, Alistair
AU - Dillon, Viv M
AU - Emrich, Scott J
AU - Fernandez-Medina, Daniela
AU - Figueiredo Gontijo, Nelder
AU - Flanley, Catherine M
AU - Gatherer, Derek
AU - Genta, Fernando A
AU - Gesing, Sandra
AU - Giraldo-Calderón, Gloria I
AU - Gomes, Bruno
AU - Aguiar, Eric Roberto Guimaraes Rocha
AU - Hamilton, James G C
AU - Hamarsheh, Omar
AU - Hawksworth, Mallory
AU - Hendershot, Jacob M
AU - Hickner, Paul V
AU - Imler, Jean-Luc
AU - Ioannidis, Panagiotis
AU - Jennings, Emily C
AU - Kamhawi, Shaden
AU - Karageorgiou, Charikleia
AU - Kennedy, Ryan C
AU - Krueger, Andreas
AU - Latorre-Estivalis, José M
AU - Ligoxygakis, Petros
AU - Meireles-Filho, Antonio Carlos A
AU - Minx, Patrick
AU - Miranda, Jose Carlos
AU - Montague, Michael J
AU - Nowling, Ronald J
AU - Oliveira, Fabiano
AU - Ortigão-Farias, João
AU - Pavan, Marcio G
AU - Sant'Anna, Mauricio R V
AU - Dillon, Rod J
PY - 2023/4/12
Y1 - 2023/4/12
N2 - Phlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. More than 40 pathogenic Leishmania species are transmitted to humans by approximately 35 sand fly species in 98 countries with hundreds of millions of people at risk around the world. No approved efficacious vaccine exists for leishmaniasis and available therapeutic drugs are either toxic and/or expensive, or the parasites are becoming resistant to the more recently developed drugs. Therefore, sand fly and/or reservoir control are currently the most effective strategies to break transmission. To better understand the biology of sand flies, including the mechanisms involved in their vectorial capacity, insecticide resistance, and population structures we sequenced the genomes of two geographically widespread and important sand fly vector species: Phlebotomus papatasi, a vector of Leishmania parasites that cause cutaneous leishmaniasis, (distributed in Europe, the Middle East and North Africa) and Lutzomyia longipalpis, a vector of Leishmania parasites that cause visceral leishmaniasis (distributed across Central and South America). We categorized and curated genes involved in processes important to their roles as disease vectors, including chemosensation, blood feeding, circadian rhythm, immunity, and detoxification, as well as mobile genetic elements. We also defined gene orthology and observed micro-synteny among the genomes. Finally, we present the genetic diversity and population structure of these species in their respective geographical areas. These genomes will be a foundation on which to base future efforts to prevent vector-borne transmission of Leishmania parasites.
AB - Phlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. More than 40 pathogenic Leishmania species are transmitted to humans by approximately 35 sand fly species in 98 countries with hundreds of millions of people at risk around the world. No approved efficacious vaccine exists for leishmaniasis and available therapeutic drugs are either toxic and/or expensive, or the parasites are becoming resistant to the more recently developed drugs. Therefore, sand fly and/or reservoir control are currently the most effective strategies to break transmission. To better understand the biology of sand flies, including the mechanisms involved in their vectorial capacity, insecticide resistance, and population structures we sequenced the genomes of two geographically widespread and important sand fly vector species: Phlebotomus papatasi, a vector of Leishmania parasites that cause cutaneous leishmaniasis, (distributed in Europe, the Middle East and North Africa) and Lutzomyia longipalpis, a vector of Leishmania parasites that cause visceral leishmaniasis (distributed across Central and South America). We categorized and curated genes involved in processes important to their roles as disease vectors, including chemosensation, blood feeding, circadian rhythm, immunity, and detoxification, as well as mobile genetic elements. We also defined gene orthology and observed micro-synteny among the genomes. Finally, we present the genetic diversity and population structure of these species in their respective geographical areas. These genomes will be a foundation on which to base future efforts to prevent vector-borne transmission of Leishmania parasites.
KW - Animals
KW - Genomics
KW - Humans
KW - Leishmania/genetics
KW - Leishmaniasis, Cutaneous
KW - Phlebotomus/parasitology
KW - Psychodidae/parasitology
U2 - 10.1371/journal.pntd.0010862
DO - 10.1371/journal.pntd.0010862
M3 - Journal article
C2 - 37043542
VL - 17
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
SN - 1935-2727
IS - 4
M1 - e0010862
ER -