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Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2.

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Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. / Nesbit, M. A.; Hodges, Matt; Campbell, L. et al.
In: Genomics, Vol. 42, No. 2, 01.06.1997, p. 284-294.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Nesbit, MA, Hodges, M, Campbell, L, de Meulemeester, TMAMO, Alders, M, Rodriques, NR, TAlbot, K, Theodosiou, AM, Mannens, MA, Nakamura, Y, Little, PFR & Davies, KE 1997, 'Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2.', Genomics, vol. 42, no. 2, pp. 284-294. https://doi.org/10.1006/geno.1997.4737

APA

Nesbit, M. A., Hodges, M., Campbell, L., de Meulemeester, T. M. A. M. O., Alders, M., Rodriques, N. R., TAlbot, K., Theodosiou, A. M., Mannens, M. A., Nakamura, Y., Little, P. F. R., & Davies, K. E. (1997). Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. Genomics, 42(2), 284-294. https://doi.org/10.1006/geno.1997.4737

Vancouver

Nesbit MA, Hodges M, Campbell L, de Meulemeester TMAMO, Alders M, Rodriques NR et al. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. Genomics. 1997 Jun 1;42(2):284-294. doi: 10.1006/geno.1997.4737

Author

Nesbit, M. A. ; Hodges, Matt ; Campbell, L. et al. / Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. In: Genomics. 1997 ; Vol. 42, No. 2. pp. 284-294.

Bibtex

@article{56cf1a39f7ce44be9a5e504f11f92425,
title = "Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2.",
abstract = "Mitogen-activated protein kinase phosphatases (MKPs) play a central role in a variety of signaling pathways. We recently described a novel murine MKP, M3/6, which is uniquely specific for c-Jun N-terminal kinase/stress-activated protein kinase and p38 kinase. Here we report the localization of the human orthologue of this gene, HB5, to within 150 kb of H19 on human chromosome 11p15.5. The gene consists of six exons. Two of the introns in HB5 are not found in other genes of this family, suggesting an evolutionary split between MKPs displaying specificity toward different MAP kinases. An intronless pseudogene is present on chromosome 10q11.2. Although 11p15.5 is an imprinted region, HB5 is almost entirely unmethylated on both alleles in lymphocytes. Chromosome 11p15 has been implicated in the development of a number of tumor types, including lung, a tissue known to express this gene. Loss of heterozygosity was found in one of eight informative lung tumors studied.",
keywords = "11p15.5",
author = "Nesbit, {M. A.} and Matt Hodges and L. Campbell and {de Meulemeester}, {T. M. A. M. O.} and M. Alders and Rodriques, {N. R.} and K. TAlbot and Theodosiou, {A. M.} and Mannens, {M. A.} and Y. Nakamura and Little, {P. F. R.} and Davies, {K. E.}",
year = "1997",
month = jun,
day = "1",
doi = "10.1006/geno.1997.4737",
language = "English",
volume = "42",
pages = "284--294",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2.

AU - Nesbit, M. A.

AU - Hodges, Matt

AU - Campbell, L.

AU - de Meulemeester, T. M. A. M. O.

AU - Alders, M.

AU - Rodriques, N. R.

AU - TAlbot, K.

AU - Theodosiou, A. M.

AU - Mannens, M. A.

AU - Nakamura, Y.

AU - Little, P. F. R.

AU - Davies, K. E.

PY - 1997/6/1

Y1 - 1997/6/1

N2 - Mitogen-activated protein kinase phosphatases (MKPs) play a central role in a variety of signaling pathways. We recently described a novel murine MKP, M3/6, which is uniquely specific for c-Jun N-terminal kinase/stress-activated protein kinase and p38 kinase. Here we report the localization of the human orthologue of this gene, HB5, to within 150 kb of H19 on human chromosome 11p15.5. The gene consists of six exons. Two of the introns in HB5 are not found in other genes of this family, suggesting an evolutionary split between MKPs displaying specificity toward different MAP kinases. An intronless pseudogene is present on chromosome 10q11.2. Although 11p15.5 is an imprinted region, HB5 is almost entirely unmethylated on both alleles in lymphocytes. Chromosome 11p15 has been implicated in the development of a number of tumor types, including lung, a tissue known to express this gene. Loss of heterozygosity was found in one of eight informative lung tumors studied.

AB - Mitogen-activated protein kinase phosphatases (MKPs) play a central role in a variety of signaling pathways. We recently described a novel murine MKP, M3/6, which is uniquely specific for c-Jun N-terminal kinase/stress-activated protein kinase and p38 kinase. Here we report the localization of the human orthologue of this gene, HB5, to within 150 kb of H19 on human chromosome 11p15.5. The gene consists of six exons. Two of the introns in HB5 are not found in other genes of this family, suggesting an evolutionary split between MKPs displaying specificity toward different MAP kinases. An intronless pseudogene is present on chromosome 10q11.2. Although 11p15.5 is an imprinted region, HB5 is almost entirely unmethylated on both alleles in lymphocytes. Chromosome 11p15 has been implicated in the development of a number of tumor types, including lung, a tissue known to express this gene. Loss of heterozygosity was found in one of eight informative lung tumors studied.

KW - 11p15.5

U2 - 10.1006/geno.1997.4737

DO - 10.1006/geno.1997.4737

M3 - Journal article

VL - 42

SP - 284

EP - 294

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -