Four, quasi-circular, positive Bouguer gravity anomalies (PBGAs) that are similar in diameter (~90–190 km) and gravitational amplitude (>140 mGal contrast) are identified within the central Oceanus Procellarum region of the Moon. These spatially associated PBGAs are located south of Aristarchus Plateau, north of Flamsteed crater, and two are within the Marius Hills volcanic complex (north and south). Each is characterized by distinct surface geologic features suggestive of ancient impact craters and/or volcanic/plutonic activity. Here, we combine geologic analyses with forward modeling of high-resolution gravity data from the Gravity Recovery and Interior Laboratory (GRAIL) mission in order to constrain the subsurface structures that contribute to these four PBGAs. The GRAIL data presented here, at spherical harmonic degrees 6–660, permit higher resolution analyses of these anomalies than previously reported, and reveal new information about subsurface structures. Specifically, we find that the amplitudes of the four PBGAs cannot be explained solely by mare-flooded craters, as suggested in previous work; an additional density contrast is required to explain the high-amplitude of the PBGAs. For Northern Flamsteed (190 km diameter), the additional density contrast may be provided by impact-related mantle uplift. If the local crust has a density ~2800 kg/m3, then ~7 km of uplift is required for this anomaly, although less uplift is required if the local crust has a lower mean density of ~2500 kg/m3. For the Northern and Southern Marius Hills anomalies, the additional density contrast is consistent with the presence of a crustal complex of vertical dikes that occupies up to ~50% of the regionally thin crust. The structure of Southern Aristarchus Plateau (90 km diameter), an anomaly with crater-related topographic structures, remains ambiguous. Based on the relatively small size of the anomaly, we do not favor mantle uplift; however, understanding mantle response in a region of especially thin crust needs to be better resolved. It is more likely that this anomaly is due to subsurface magmatic material given the abundance of volcanic material in the surrounding region. Overall, the four PBGAs analyzed here are important in understanding the impact and volcanic/plutonic history of the Moon, specifically in a region of thin crust and elevated temperatures characteristic of the Procellarum KREEP Terrane.