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Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

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Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. / Gaffney, Christopher James; Pollard, Amelia; Barratt, Thomas et al.

In: Aging, Vol. 10, No. 11, 2018, p. 3382—3396.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Gaffney, CJ, Pollard, A, Barratt, T, Constantin-Teodosiu, D, Greenhaff, PL & Szewczyk, N 2018, 'Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans', Aging, vol. 10, no. 11, pp. 3382—3396. https://doi.org/10.18632/aging.101654

APA

Gaffney, C. J., Pollard, A., Barratt, T., Constantin-Teodosiu, D., Greenhaff, P. L., & Szewczyk, N. (2018). Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. Aging, 10(11), 3382—3396. https://doi.org/10.18632/aging.101654

Vancouver

Gaffney CJ, Pollard A, Barratt T, Constantin-Teodosiu D, Greenhaff PL, Szewczyk N. Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. Aging. 2018;10(11):3382—3396. Epub 2018 Nov 19. doi: 10.18632/aging.101654

Author

Gaffney, Christopher James ; Pollard, Amelia ; Barratt, Thomas et al. / Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. In: Aging. 2018 ; Vol. 10, No. 11. pp. 3382—3396.

Bibtex

@article{7f70abfbf5b14f84a7c5d10b65ad976c,
title = "Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans",
abstract = "Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here, we use C. elegans natural scaling of lifespan in response to temperature to examine the relationship between mitochondrial content, mitochondrial function, and sarcopenia. Mitochondrial content and maximal mitochondrial ATP production rates (MAPR) display an inverse relationship to lifespan, while onset of MAPR decline displays a direct relationship. Muscle mitochondrial structure, sarcomere structure, and movement decline also display a direct relationship with longevity. Notably, the decline in mitochondrial network structure occurs earlier than sarcomere decline, and correlates more strongly with loss of movement, and scales with lifespan. These results suggest that mitochondrial function is critical in the ageing process and more robustly explains the onset and progression of sarcopenia than loss of sarcomere structure.",
keywords = "sarcopenia, ageing, muscle, C. elegans, mitochondria, ATP production, sarcomere",
author = "Gaffney, {Christopher James} and Amelia Pollard and Thomas Barratt and Dumitru Constantin-Teodosiu and Greenhaff, {Paul L} and Nathaniel Szewczyk",
year = "2018",
doi = "10.18632/aging.101654",
language = "English",
volume = "10",
pages = "3382—3396",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals",
number = "11",

}

RIS

TY - JOUR

T1 - Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

AU - Gaffney, Christopher James

AU - Pollard, Amelia

AU - Barratt, Thomas

AU - Constantin-Teodosiu, Dumitru

AU - Greenhaff, Paul L

AU - Szewczyk, Nathaniel

PY - 2018

Y1 - 2018

N2 - Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here, we use C. elegans natural scaling of lifespan in response to temperature to examine the relationship between mitochondrial content, mitochondrial function, and sarcopenia. Mitochondrial content and maximal mitochondrial ATP production rates (MAPR) display an inverse relationship to lifespan, while onset of MAPR decline displays a direct relationship. Muscle mitochondrial structure, sarcomere structure, and movement decline also display a direct relationship with longevity. Notably, the decline in mitochondrial network structure occurs earlier than sarcomere decline, and correlates more strongly with loss of movement, and scales with lifespan. These results suggest that mitochondrial function is critical in the ageing process and more robustly explains the onset and progression of sarcopenia than loss of sarcomere structure.

AB - Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here, we use C. elegans natural scaling of lifespan in response to temperature to examine the relationship between mitochondrial content, mitochondrial function, and sarcopenia. Mitochondrial content and maximal mitochondrial ATP production rates (MAPR) display an inverse relationship to lifespan, while onset of MAPR decline displays a direct relationship. Muscle mitochondrial structure, sarcomere structure, and movement decline also display a direct relationship with longevity. Notably, the decline in mitochondrial network structure occurs earlier than sarcomere decline, and correlates more strongly with loss of movement, and scales with lifespan. These results suggest that mitochondrial function is critical in the ageing process and more robustly explains the onset and progression of sarcopenia than loss of sarcomere structure.

KW - sarcopenia

KW - ageing

KW - muscle

KW - C. elegans

KW - mitochondria

KW - ATP production

KW - sarcomere

U2 - 10.18632/aging.101654

DO - 10.18632/aging.101654

M3 - Journal article

VL - 10

SP - 3382—3396

JO - Aging

JF - Aging

SN - 1945-4589

IS - 11

ER -