Home > Research > Publications & Outputs > Headspace analysis of new psychoactive substanc...

Electronic data

  • 1-s2.0-S1387380613004454-main

    Rights statement: Open Access funded by Biotechnology and Biological Sciences Research Council Under a Creative Commons license

    Final published version, 1.53 MB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

Links

Text available via DOI:

View graph of relations

Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer

Research output: Contribution to journalJournal articlepeer-review

Published
  • Joe Acton
  • Matteo Lanza
  • Bishu Agarwal
  • Simone Jürschik
  • Philipp Sulzer
  • Kostiantyn Breiev
  • Alfons Jordan
  • Eugen Hartungen
  • Gernot Hanel
  • Lukas Märk
  • Chris A. Mayhew
  • Tilmann D. Märk
Close
<mark>Journal publication date</mark>1/03/2014
<mark>Journal</mark>International Journal of Mass Spectrometry
Volume360
Number of pages11
Pages (from-to)28-38
Publication StatusPublished
Early online date22/12/13
<mark>Original language</mark>English

Abstract

The rapid expansion in the number and use of new psychoactive substances presents a significant analytical challenge because highly sensitive instrumentation capable of detecting a broad range of chemical compounds in real-time with a low rate of false positives is required. A Selective Reagent Ionisation-Time of Flight-Mass Spectrometry (SRI-ToF-MS) instrument is capable of meeting all of these requirements. With its high mass resolution (up to m/Δm of 8000), the application of variations in reduced electric field strength (E/N) and use of different reagent ions, the ambiguity of a nominal (monoisotopic) m/z is reduced and hence the identification of chemicals in a complex chemical environment with a high level of confidence is enabled. In this study we report the use of a SRI-ToF-MS instrument to investigate the reactions of H3O+, O2+, NO+ and Kr+ with 10 readily available (at the time of purchase) new psychoactive substances, namely 4-fluoroamphetamine, methiopropamine, ethcathinone, 4-methylethcathinone, N-ethylbuphedrone, ethylphenidate, 5-MeO-DALT, dimethocaine, 5-(2-aminopropyl)benzofuran and nitracaine. In particular, the dependence of product ion branching ratios on the reduced electric field strength for all reagent ions was investigated and is reported here. The results reported represent a significant amount of new data which will be of use for the development of drug detection techniques suitable for real world scenarios.

Bibliographic note

Open Access funded by Biotechnology and Biological Sciences Research Council Under a Creative Commons license