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Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come

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Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come. / Faniyi, A.A.; Wijanarko, K.J.; Tollitt, J. et al.
In: Frontiers in Immunology, Vol. 11, 1489, 30.07.2020.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Faniyi AA, Wijanarko KJ, Tollitt J, Worthington JJ. Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come. Frontiers in Immunology. 2020 Jul 30;11:1489. doi: 10.3389/fimmu.2020.01489

Author

Faniyi, A.A. ; Wijanarko, K.J. ; Tollitt, J. et al. / Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come. In: Frontiers in Immunology. 2020 ; Vol. 11.

Bibtex

@article{77bff5f9f7fc49359be1ff8fb5b5cefe,
title = "Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come",
abstract = "Human intestinal helminth infection affects more than 1 billion people often in the world's most deprived communities. These parasites are one of the most prevalent neglected tropical diseases worldwide bringing huge morbidities to the host population. Effective treatments and vaccines for helminths are currently limited, and therefore, it is essential to understand the molecular sensors that the intestinal epithelium utilizes in detecting helminths and how the responding factors produced act as modulators of immunity. Defining the cellular and molecular mechanisms that enable helminth detection and expulsion will be critical in identifying potential therapeutic targets to alleviate disease. However, despite decades of research, we have only recently been able to identify the tuft cell as a key helminth sensor at the epithelial barrier. In this review, we will highlight the key intestinal epithelial chemosensory roles associated with the detection of intestinal helminths, summarizing the recent advances in tuft cell initiation of protective type 2 immunity. We will discuss other potential sensory roles of epithelial subsets and introduce enteroendocrine cells as potential key sensors of the microbial alterations that a helminth infection produces, which, given their direct communication to the nervous system via the recently described neuropod, have the potential to transfer the epithelial immune interface systemically. {\textcopyright} Copyright {\textcopyright} 2020 Faniyi, Wijanarko, Tollitt and Worthington.",
keywords = "enteroendocrine cell (EEC), epithelium, G protein-coupled receptor (GPCR), helminth, microbiome, tuft cells",
author = "A.A. Faniyi and K.J. Wijanarko and J. Tollitt and J.J. Worthington",
year = "2020",
month = jul,
day = "30",
doi = "10.3389/fimmu.2020.01489",
language = "English",
volume = "11",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come

AU - Faniyi, A.A.

AU - Wijanarko, K.J.

AU - Tollitt, J.

AU - Worthington, J.J.

PY - 2020/7/30

Y1 - 2020/7/30

N2 - Human intestinal helminth infection affects more than 1 billion people often in the world's most deprived communities. These parasites are one of the most prevalent neglected tropical diseases worldwide bringing huge morbidities to the host population. Effective treatments and vaccines for helminths are currently limited, and therefore, it is essential to understand the molecular sensors that the intestinal epithelium utilizes in detecting helminths and how the responding factors produced act as modulators of immunity. Defining the cellular and molecular mechanisms that enable helminth detection and expulsion will be critical in identifying potential therapeutic targets to alleviate disease. However, despite decades of research, we have only recently been able to identify the tuft cell as a key helminth sensor at the epithelial barrier. In this review, we will highlight the key intestinal epithelial chemosensory roles associated with the detection of intestinal helminths, summarizing the recent advances in tuft cell initiation of protective type 2 immunity. We will discuss other potential sensory roles of epithelial subsets and introduce enteroendocrine cells as potential key sensors of the microbial alterations that a helminth infection produces, which, given their direct communication to the nervous system via the recently described neuropod, have the potential to transfer the epithelial immune interface systemically. © Copyright © 2020 Faniyi, Wijanarko, Tollitt and Worthington.

AB - Human intestinal helminth infection affects more than 1 billion people often in the world's most deprived communities. These parasites are one of the most prevalent neglected tropical diseases worldwide bringing huge morbidities to the host population. Effective treatments and vaccines for helminths are currently limited, and therefore, it is essential to understand the molecular sensors that the intestinal epithelium utilizes in detecting helminths and how the responding factors produced act as modulators of immunity. Defining the cellular and molecular mechanisms that enable helminth detection and expulsion will be critical in identifying potential therapeutic targets to alleviate disease. However, despite decades of research, we have only recently been able to identify the tuft cell as a key helminth sensor at the epithelial barrier. In this review, we will highlight the key intestinal epithelial chemosensory roles associated with the detection of intestinal helminths, summarizing the recent advances in tuft cell initiation of protective type 2 immunity. We will discuss other potential sensory roles of epithelial subsets and introduce enteroendocrine cells as potential key sensors of the microbial alterations that a helminth infection produces, which, given their direct communication to the nervous system via the recently described neuropod, have the potential to transfer the epithelial immune interface systemically. © Copyright © 2020 Faniyi, Wijanarko, Tollitt and Worthington.

KW - enteroendocrine cell (EEC)

KW - epithelium

KW - G protein-coupled receptor (GPCR)

KW - helminth

KW - microbiome

KW - tuft cells

U2 - 10.3389/fimmu.2020.01489

DO - 10.3389/fimmu.2020.01489

M3 - Journal article

VL - 11

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 1489

ER -