Final published version
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Final published version
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Research output: Contribution to specialist publication › Featured article
Research output: Contribution to specialist publication › Featured article
}
TY - GEN
T1 - Herpesviridae
AU - Gatherer, Derek
AU - Depledge, Daniel P
AU - Hartley, Carol
AU - Szpara, Moriah L
AU - Vaz, Paola
AU - Benko, Maria
AU - Brandt, Curtis
AU - Bryant, Neil
AU - Dastjerdi, Akbar
AU - Doszpoly, Andor
AU - Gompels, Ursula
AU - Inoue, Naoki
AU - Jarosinski, Keith
AU - Kaul, Rajeev
AU - Lacoste, Vincent
AU - Norberg, Peter
AU - Origgi, Francesco
AU - Orton, Richard
AU - Pellett, Philip
AU - Schmid, Scott
AU - Spatz, Stephen
AU - Stewart, James P
AU - Trimpert, Jakob
AU - Waltzek, Thomas B
AU - Davison, Andrew J.
PY - 2021/10/27
Y1 - 2021/10/27
N2 - Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components (Table 1.Herpesviridae). The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 genes, of which 43 have been inherited from an ancestral herpesvirus. Herpesviruses have generally coevolved with their hosts and are highly adapted to them, and are likely to be associated with most mammalian, avian and reptilian species. Following primary infection, they are able to establish life-long latent infection, during which there is limited viral gene expression. Severe disease is usually observed only in the foetus, the very young, the immunocompromised or following infection of an alternative host.
AB - Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components (Table 1.Herpesviridae). The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 genes, of which 43 have been inherited from an ancestral herpesvirus. Herpesviruses have generally coevolved with their hosts and are highly adapted to them, and are likely to be associated with most mammalian, avian and reptilian species. Following primary infection, they are able to establish life-long latent infection, during which there is limited viral gene expression. Severe disease is usually observed only in the foetus, the very young, the immunocompromised or following infection of an alternative host.
KW - Herpesviridae
KW - herpesvirus
KW - Herpesvirales
KW - herpes
U2 - 10.1099/jgv.0.001673
DO - 10.1099/jgv.0.001673
M3 - Featured article
VL - 102
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
ER -