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Heterogeneity in antibody range and the antigenic drift of influenza A viruses

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Heterogeneity in antibody range and the antigenic drift of influenza A viruses. / Parisi, Andrea; Lopes, Joao S.; Nunes, Ana et al.
In: Ecological Complexity, Vol. 14, 06.2013, p. 157-165.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Parisi, A, Lopes, JS, Nunes, A & Gomes, MGM 2013, 'Heterogeneity in antibody range and the antigenic drift of influenza A viruses', Ecological Complexity, vol. 14, pp. 157-165. https://doi.org/10.1016/j.ecocom.2012.12.001

APA

Parisi, A., Lopes, J. S., Nunes, A., & Gomes, M. G. M. (2013). Heterogeneity in antibody range and the antigenic drift of influenza A viruses. Ecological Complexity, 14, 157-165. https://doi.org/10.1016/j.ecocom.2012.12.001

Vancouver

Parisi A, Lopes JS, Nunes A, Gomes MGM. Heterogeneity in antibody range and the antigenic drift of influenza A viruses. Ecological Complexity. 2013 Jun;14:157-165. Epub 2013 Jan 18. doi: 10.1016/j.ecocom.2012.12.001

Author

Parisi, Andrea ; Lopes, Joao S. ; Nunes, Ana et al. / Heterogeneity in antibody range and the antigenic drift of influenza A viruses. In: Ecological Complexity. 2013 ; Vol. 14. pp. 157-165.

Bibtex

@article{b485ebce0d604a218c64a4a304b6c185,
title = "Heterogeneity in antibody range and the antigenic drift of influenza A viruses",
abstract = "In this paper we explore the consequences of a heterogeneous immune response in individuals on the evolution of a rapidly mutating virus. We show that several features of the incidence and phylogenetic patterns typical of influenza A may be understood in this framework. In our model, limited diversity and rapid drift of the circulating viral strains result from the interplay of two interacting subpopulations with different types of immune response, narrow or broad, upon infection. The subpopulation with the narrow immune response acts as a reservoir where consecutive mutations escape immunity and can persist. Strains with a number of accumulated mutations escape immunity in the other subpopulation as well, causing larger epidemic peaks in the whole population, and reducing strain diversity. Overall, our model produces a modulation of epidemic peak heights and patterns of antigenic drift consistent with reported observations, suggesting an underlying mechanism for the evolutionary epidemiology of influenza, in particular, and other infectious diseases, more generally.",
keywords = "Antigenic drift, Evolution, Immune escape, Immune response, Influenza",
author = "Andrea Parisi and Lopes, {Joao S.} and Ana Nunes and Gomes, {M. Gabriela M}",
year = "2013",
month = jun,
doi = "10.1016/j.ecocom.2012.12.001",
language = "English",
volume = "14",
pages = "157--165",
journal = "Ecological Complexity",
issn = "1476-945X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Heterogeneity in antibody range and the antigenic drift of influenza A viruses

AU - Parisi, Andrea

AU - Lopes, Joao S.

AU - Nunes, Ana

AU - Gomes, M. Gabriela M

PY - 2013/6

Y1 - 2013/6

N2 - In this paper we explore the consequences of a heterogeneous immune response in individuals on the evolution of a rapidly mutating virus. We show that several features of the incidence and phylogenetic patterns typical of influenza A may be understood in this framework. In our model, limited diversity and rapid drift of the circulating viral strains result from the interplay of two interacting subpopulations with different types of immune response, narrow or broad, upon infection. The subpopulation with the narrow immune response acts as a reservoir where consecutive mutations escape immunity and can persist. Strains with a number of accumulated mutations escape immunity in the other subpopulation as well, causing larger epidemic peaks in the whole population, and reducing strain diversity. Overall, our model produces a modulation of epidemic peak heights and patterns of antigenic drift consistent with reported observations, suggesting an underlying mechanism for the evolutionary epidemiology of influenza, in particular, and other infectious diseases, more generally.

AB - In this paper we explore the consequences of a heterogeneous immune response in individuals on the evolution of a rapidly mutating virus. We show that several features of the incidence and phylogenetic patterns typical of influenza A may be understood in this framework. In our model, limited diversity and rapid drift of the circulating viral strains result from the interplay of two interacting subpopulations with different types of immune response, narrow or broad, upon infection. The subpopulation with the narrow immune response acts as a reservoir where consecutive mutations escape immunity and can persist. Strains with a number of accumulated mutations escape immunity in the other subpopulation as well, causing larger epidemic peaks in the whole population, and reducing strain diversity. Overall, our model produces a modulation of epidemic peak heights and patterns of antigenic drift consistent with reported observations, suggesting an underlying mechanism for the evolutionary epidemiology of influenza, in particular, and other infectious diseases, more generally.

KW - Antigenic drift

KW - Evolution

KW - Immune escape

KW - Immune response

KW - Influenza

U2 - 10.1016/j.ecocom.2012.12.001

DO - 10.1016/j.ecocom.2012.12.001

M3 - Journal article

AN - SCOPUS:84877153145

VL - 14

SP - 157

EP - 165

JO - Ecological Complexity

JF - Ecological Complexity

SN - 1476-945X

ER -