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HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 Is Required for Circadian Periodicity through the Promotion of Nucleo-Cytoplasmic mRNA Export in Arabidopsis

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Dana MacGregor
  • Peter Gould
  • Julia Foreman
  • Jayne Griffiths
  • Susannah Bird
  • Rhiannon Page
  • Kelly Stewart
  • Gavin Steel
  • Jack Young
  • Konrad Paszkiewicz
  • Andrew Millar
  • Karen Halliday
  • Anthony Hall
  • Steven Penfield
<mark>Journal publication date</mark>11/2013
<mark>Journal</mark>The Plant Cell
Issue number11
Number of pages14
Pages (from-to)4391-4404
Publication StatusPublished
<mark>Original language</mark>English


Cold acclimation has been shown to be attenuated by the degradation of the INDUCER OF CBF EXPRESSION1 protein by the E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 (HOS1). However, recent work has suggested that HOS1 may have a wider range of roles in plants than previously appreciated. Here, we show that hos1 mutants are affected in circadian clock function, exhibiting a long-period phenotype in a wide range of temperature and light environments. We demonstrate that hos1 mutants accumulate polyadenylated mRNA in the nucleus and that the circadian defect in hos1 is shared by multiple mutants with aberrant mRNA export, but not in a mutant attenuated in nucleo-cytoplasmic transport of microRNAs. As revealed by RNA sequencing, hos1 exhibits gross changes to the transcriptome with genes in multiple functional categories being affected. In addition, we show that hos1 and other previously described mutants with altered mRNA export affect cold signaling in a similar manner. Our data support a model in which altered mRNA export is important for the manifestation of hos1 circadian clock defects and suggest that HOS1 may indirectly affect cold signaling through disruption of the circadian clock.