TY - JOUR

T1 - Horizons in nutritional science : The case for strategic international alliances to harness nutritional genomics for public and personal health.

AU - Chadwick, Ruth, et al.

N1 - http://journals.cambridge.org/action/displayJournal?jid=BJN The final, definitive version of this article has been published in the Journal, British Journal of Nutrition, 94 (5), pp 623-632 2005, © 2005 Cambridge University Press.

PY - 2005/11

Y1 - 2005/11

N2 - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

AB - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

KW - Strategic international alliances

KW - Nutrigenomics

KW - Gene–nutrient interactions

KW - Health diaparities

U2 - 10.1079/BJN20051585

DO - 10.1079/BJN20051585

M3 - Journal article

VL - 94

SP - 623

EP - 632

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 1475-2662

IS - 5

ER -