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Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study

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Household air pollution, chronic respiratory disease and pneumonia in Malawian adults : A case-control study. / Jary, Hannah R.; Aston, Stephen; Ho, Antonio; Giorgi, Emanuele; Kalata, Newton; Nyirenda, Mulinda; Mallewa, Jane; Peterson, Ingrid; Gordon, Stephen B.; Mortimer, Kevin.

In: Wellcome Open Research, Vol. 2, 103, 24.10.2017.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Jary, HR, Aston, S, Ho, A, Giorgi, E, Kalata, N, Nyirenda, M, Mallewa, J, Peterson, I, Gordon, SB & Mortimer, K 2017, 'Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study', Wellcome Open Research, vol. 2, 103. https://doi.org/10.12688/wellcomeopenres.12621.1

APA

Jary, H. R., Aston, S., Ho, A., Giorgi, E., Kalata, N., Nyirenda, M., Mallewa, J., Peterson, I., Gordon, S. B., & Mortimer, K. (2017). Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study. Wellcome Open Research, 2, [103]. https://doi.org/10.12688/wellcomeopenres.12621.1

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Author

Jary, Hannah R. ; Aston, Stephen ; Ho, Antonio ; Giorgi, Emanuele ; Kalata, Newton ; Nyirenda, Mulinda ; Mallewa, Jane ; Peterson, Ingrid ; Gordon, Stephen B. ; Mortimer, Kevin. / Household air pollution, chronic respiratory disease and pneumonia in Malawian adults : A case-control study. In: Wellcome Open Research. 2017 ; Vol. 2.

Bibtex

@article{09e45b4c87fc4be191d0d41b62fb356d,
title = "Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study",
abstract = "Background: Four million people die each year from diseases caused by exposure to household air pollution. There is an association between exposure to household air pollution and pneumonia in children (half a million attributable deaths a year); however, whether this is true in adults is unknown. We conducted a case-control study in urban Malawi to examine the association between exposure to household air pollution and pneumonia in adults. Methods: Hospitalized patients with radiologically confirmed pneumonia (cases) and healthy community controls underwent 48 hours of ambulatory and household particulate matter (µg/m3) and carbon monoxide (ppm) exposure monitoring. Multivariate logistic regression, stratified by HIV status, explored associations between these and other potential risk factors with pneumonia. Results: 145 (117 HIV-positive; 28 HIV-negative) cases and 253 (169 HIV-positive; 84 HIV-negative) controls completed follow up. We found no evidence of association between household air pollution exposure and pneumonia in HIV-positive (e.g. ambulatory particulate matter adjusted odds ratio [aOR] 1.00 [95% CI 1.00–1.01, p=0.141]) or HIV-negative (e.g. ambulatory particulate matter aOR 1.00 [95% CI 0.99–1.01, p=0.872]) participants. Chronic respiratory disease was associated with pneumonia in both HIV-positive (aOR 28.07 [95% CI 9.29–84.83, p<0.001]) and HIV-negative (aOR 104.27 [95% CI 12.86–852.35, p<0.001]) participants. Conclusions: We found no evidence that exposure to household air pollution is associated with pneumonia in Malawian adults. In contrast, chronic respiratory disease was strongly associated with pneumonia.",
author = "Jary, {Hannah R.} and Stephen Aston and Antonio Ho and Emanuele Giorgi and Newton Kalata and Mulinda Nyirenda and Jane Mallewa and Ingrid Peterson and Gordon, {Stephen B.} and Kevin Mortimer",
year = "2017",
month = oct,
day = "24",
doi = "10.12688/wellcomeopenres.12621.1",
language = "English",
volume = "2",
journal = "Wellcome Open Research",
issn = "2398-502X",
publisher = "F1000 Research Ltd.",

}

RIS

TY - JOUR

T1 - Household air pollution, chronic respiratory disease and pneumonia in Malawian adults

T2 - A case-control study

AU - Jary, Hannah R.

AU - Aston, Stephen

AU - Ho, Antonio

AU - Giorgi, Emanuele

AU - Kalata, Newton

AU - Nyirenda, Mulinda

AU - Mallewa, Jane

AU - Peterson, Ingrid

AU - Gordon, Stephen B.

AU - Mortimer, Kevin

PY - 2017/10/24

Y1 - 2017/10/24

N2 - Background: Four million people die each year from diseases caused by exposure to household air pollution. There is an association between exposure to household air pollution and pneumonia in children (half a million attributable deaths a year); however, whether this is true in adults is unknown. We conducted a case-control study in urban Malawi to examine the association between exposure to household air pollution and pneumonia in adults. Methods: Hospitalized patients with radiologically confirmed pneumonia (cases) and healthy community controls underwent 48 hours of ambulatory and household particulate matter (µg/m3) and carbon monoxide (ppm) exposure monitoring. Multivariate logistic regression, stratified by HIV status, explored associations between these and other potential risk factors with pneumonia. Results: 145 (117 HIV-positive; 28 HIV-negative) cases and 253 (169 HIV-positive; 84 HIV-negative) controls completed follow up. We found no evidence of association between household air pollution exposure and pneumonia in HIV-positive (e.g. ambulatory particulate matter adjusted odds ratio [aOR] 1.00 [95% CI 1.00–1.01, p=0.141]) or HIV-negative (e.g. ambulatory particulate matter aOR 1.00 [95% CI 0.99–1.01, p=0.872]) participants. Chronic respiratory disease was associated with pneumonia in both HIV-positive (aOR 28.07 [95% CI 9.29–84.83, p<0.001]) and HIV-negative (aOR 104.27 [95% CI 12.86–852.35, p<0.001]) participants. Conclusions: We found no evidence that exposure to household air pollution is associated with pneumonia in Malawian adults. In contrast, chronic respiratory disease was strongly associated with pneumonia.

AB - Background: Four million people die each year from diseases caused by exposure to household air pollution. There is an association between exposure to household air pollution and pneumonia in children (half a million attributable deaths a year); however, whether this is true in adults is unknown. We conducted a case-control study in urban Malawi to examine the association between exposure to household air pollution and pneumonia in adults. Methods: Hospitalized patients with radiologically confirmed pneumonia (cases) and healthy community controls underwent 48 hours of ambulatory and household particulate matter (µg/m3) and carbon monoxide (ppm) exposure monitoring. Multivariate logistic regression, stratified by HIV status, explored associations between these and other potential risk factors with pneumonia. Results: 145 (117 HIV-positive; 28 HIV-negative) cases and 253 (169 HIV-positive; 84 HIV-negative) controls completed follow up. We found no evidence of association between household air pollution exposure and pneumonia in HIV-positive (e.g. ambulatory particulate matter adjusted odds ratio [aOR] 1.00 [95% CI 1.00–1.01, p=0.141]) or HIV-negative (e.g. ambulatory particulate matter aOR 1.00 [95% CI 0.99–1.01, p=0.872]) participants. Chronic respiratory disease was associated with pneumonia in both HIV-positive (aOR 28.07 [95% CI 9.29–84.83, p<0.001]) and HIV-negative (aOR 104.27 [95% CI 12.86–852.35, p<0.001]) participants. Conclusions: We found no evidence that exposure to household air pollution is associated with pneumonia in Malawian adults. In contrast, chronic respiratory disease was strongly associated with pneumonia.

U2 - 10.12688/wellcomeopenres.12621.1

DO - 10.12688/wellcomeopenres.12621.1

M3 - Journal article

VL - 2

JO - Wellcome Open Research

JF - Wellcome Open Research

SN - 2398-502X

M1 - 103

ER -