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Human chromosome 17 in essential hypertension

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Human chromosome 17 in essential hypertension. / Knight, Jo; Munroe, P. B.; Pembroke, J. C. et al.
In: Annals of Human Genetics, Vol. 67, No. 2, 03.2003, p. 193-206.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Knight, J, Munroe, PB, Pembroke, JC & Caulfield, MJ 2003, 'Human chromosome 17 in essential hypertension', Annals of Human Genetics, vol. 67, no. 2, pp. 193-206. https://doi.org/10.1046/j.1469-1809.2003.t01-1-00002.x

APA

Knight, J., Munroe, P. B., Pembroke, J. C., & Caulfield, M. J. (2003). Human chromosome 17 in essential hypertension. Annals of Human Genetics, 67(2), 193-206. https://doi.org/10.1046/j.1469-1809.2003.t01-1-00002.x

Vancouver

Knight J, Munroe PB, Pembroke JC, Caulfield MJ. Human chromosome 17 in essential hypertension. Annals of Human Genetics. 2003 Mar;67(2):193-206. Epub 2003 Mar 7. doi: 10.1046/j.1469-1809.2003.t01-1-00002.x

Author

Knight, Jo ; Munroe, P. B. ; Pembroke, J. C. et al. / Human chromosome 17 in essential hypertension. In: Annals of Human Genetics. 2003 ; Vol. 67, No. 2. pp. 193-206.

Bibtex

@article{72d3c6b3ef884ef8859bb01ffdcf59ed,
title = "Human chromosome 17 in essential hypertension",
abstract = "Hypertension affects up to 30% of the adult population in Western societies and is a major risk factor for kidney disease, stroke and coronary heart disease. It is a complex trait thought to be influenced by a number of genes and environmental factors, although the precise aetiology remains unknown at this time. A number of methods have been successfully used to identify mutations that cause Mendelian traits and these are now being applied to the investigation of complex diseases. This review summarises the data gathered, using such approaches, that suggest there is a gene or genes on chromosome 17 causing human essential hypertension. Studies in rodent models are discussed first, followed by studies of human hypertension that include the investigation of pseudohypoaldosteronism type II, a monogenic trait that manifests with hypertension alongside other phenotypic variables. In addition, candidate gene studies, genome screens and linkage studies based on comparative mapping are outlined. To date no gene has been identified on human chromosome 17 that influences blood pressure and causes human essential hypertension. However, results of ongoing fine mapping and candidate gene studies in both rodents and man are eagerly awaited.",
keywords = "Animals, Blood Pressure, Chromosome Mapping, Chromosomes, Human, Pair 17, Disease Models, Animal, Genetic Linkage, Genetic Markers, Humans, Hypertension, Mice, Peptidyl-Dipeptidase A, Phenotype, Pseudohypoaldosteronism, Quantitative Trait Loci, Rats, Rats, Inbred SHR",
author = "Jo Knight and Munroe, {P. B.} and Pembroke, {J. C.} and Caulfield, {M. J.}",
year = "2003",
month = mar,
doi = "10.1046/j.1469-1809.2003.t01-1-00002.x",
language = "English",
volume = "67",
pages = "193--206",
journal = "Annals of Human Genetics",
issn = "0003-4800",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Human chromosome 17 in essential hypertension

AU - Knight, Jo

AU - Munroe, P. B.

AU - Pembroke, J. C.

AU - Caulfield, M. J.

PY - 2003/3

Y1 - 2003/3

N2 - Hypertension affects up to 30% of the adult population in Western societies and is a major risk factor for kidney disease, stroke and coronary heart disease. It is a complex trait thought to be influenced by a number of genes and environmental factors, although the precise aetiology remains unknown at this time. A number of methods have been successfully used to identify mutations that cause Mendelian traits and these are now being applied to the investigation of complex diseases. This review summarises the data gathered, using such approaches, that suggest there is a gene or genes on chromosome 17 causing human essential hypertension. Studies in rodent models are discussed first, followed by studies of human hypertension that include the investigation of pseudohypoaldosteronism type II, a monogenic trait that manifests with hypertension alongside other phenotypic variables. In addition, candidate gene studies, genome screens and linkage studies based on comparative mapping are outlined. To date no gene has been identified on human chromosome 17 that influences blood pressure and causes human essential hypertension. However, results of ongoing fine mapping and candidate gene studies in both rodents and man are eagerly awaited.

AB - Hypertension affects up to 30% of the adult population in Western societies and is a major risk factor for kidney disease, stroke and coronary heart disease. It is a complex trait thought to be influenced by a number of genes and environmental factors, although the precise aetiology remains unknown at this time. A number of methods have been successfully used to identify mutations that cause Mendelian traits and these are now being applied to the investigation of complex diseases. This review summarises the data gathered, using such approaches, that suggest there is a gene or genes on chromosome 17 causing human essential hypertension. Studies in rodent models are discussed first, followed by studies of human hypertension that include the investigation of pseudohypoaldosteronism type II, a monogenic trait that manifests with hypertension alongside other phenotypic variables. In addition, candidate gene studies, genome screens and linkage studies based on comparative mapping are outlined. To date no gene has been identified on human chromosome 17 that influences blood pressure and causes human essential hypertension. However, results of ongoing fine mapping and candidate gene studies in both rodents and man are eagerly awaited.

KW - Animals

KW - Blood Pressure

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 17

KW - Disease Models, Animal

KW - Genetic Linkage

KW - Genetic Markers

KW - Humans

KW - Hypertension

KW - Mice

KW - Peptidyl-Dipeptidase A

KW - Phenotype

KW - Pseudohypoaldosteronism

KW - Quantitative Trait Loci

KW - Rats

KW - Rats, Inbred SHR

U2 - 10.1046/j.1469-1809.2003.t01-1-00002.x

DO - 10.1046/j.1469-1809.2003.t01-1-00002.x

M3 - Journal article

C2 - 12675695

VL - 67

SP - 193

EP - 206

JO - Annals of Human Genetics

JF - Annals of Human Genetics

SN - 0003-4800

IS - 2

ER -