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Hydatidiform mole: An ultrastructural analysis of syncytiotrophoblast surface organization

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Hydatidiform mole: An ultrastructural analysis of syncytiotrophoblast surface organization. / Ockleford, Colin; Barker, Caroline; Griffiths, Janet et al.
In: Placenta, Vol. 10, No. 2, 01.01.1989, p. 195-212.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Ockleford, C, Barker, C, Griffiths, J, McTurk, G, Fisher, R & Lawler, S 1989, 'Hydatidiform mole: An ultrastructural analysis of syncytiotrophoblast surface organization', Placenta, vol. 10, no. 2, pp. 195-212. https://doi.org/10.1016/0143-4004(89)90040-4

APA

Ockleford, C., Barker, C., Griffiths, J., McTurk, G., Fisher, R., & Lawler, S. (1989). Hydatidiform mole: An ultrastructural analysis of syncytiotrophoblast surface organization. Placenta, 10(2), 195-212. https://doi.org/10.1016/0143-4004(89)90040-4

Vancouver

Ockleford C, Barker C, Griffiths J, McTurk G, Fisher R, Lawler S. Hydatidiform mole: An ultrastructural analysis of syncytiotrophoblast surface organization. Placenta. 1989 Jan 1;10(2):195-212. doi: 10.1016/0143-4004(89)90040-4

Author

Ockleford, Colin ; Barker, Caroline ; Griffiths, Janet et al. / Hydatidiform mole : An ultrastructural analysis of syncytiotrophoblast surface organization. In: Placenta. 1989 ; Vol. 10, No. 2. pp. 195-212.

Bibtex

@article{abd2d73b73bd4e0391165618853f260b,
title = "Hydatidiform mole: An ultrastructural analysis of syncytiotrophoblast surface organization",
abstract = "The scanning ultrastructural examination of a series of 31 hydatidiform mole and 12 healthy placental specimens of similar gestational age has revealed a variety of surface architectures more common in molar tissue. Characteristic paddle-shaped sprouts, ridging of the syncytial maternal oriented surface and microgibbosities are described. These structures are explicable in terms of organellar hyperplasia of cortical cytoskeletal elements found in healthy tissue. Specific morphological evidence of involvement of these elements in a condition where aberrant growth control leads to the characteristic trophoblastic hyperplasia is a further indication that cytoskeletal elements may mediate transformation. An increase in resolution obtained over previous scanning electron microscope studies has allowed the description of detailed features such as 'caveolar collars' on the maternal oriented healthy and molar trophoblast surfaces. These observations are of relevance to understanding the mechanisms of several cell physiological processes, including transepithelial transport. New observations of a reticular organization in the surface layer of molar trophoblast indicate that a syncytioskeletal layer, with organization resembling that previously described in healthy chorionic villi, is also present in molar villi.",
author = "Colin Ockleford and Caroline Barker and Janet Griffiths and George McTurk and Rosemary Fisher and Sylvia Lawler",
year = "1989",
month = jan,
day = "1",
doi = "10.1016/0143-4004(89)90040-4",
language = "English",
volume = "10",
pages = "195--212",
journal = "Placenta",
issn = "0143-4004",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Hydatidiform mole

T2 - An ultrastructural analysis of syncytiotrophoblast surface organization

AU - Ockleford, Colin

AU - Barker, Caroline

AU - Griffiths, Janet

AU - McTurk, George

AU - Fisher, Rosemary

AU - Lawler, Sylvia

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The scanning ultrastructural examination of a series of 31 hydatidiform mole and 12 healthy placental specimens of similar gestational age has revealed a variety of surface architectures more common in molar tissue. Characteristic paddle-shaped sprouts, ridging of the syncytial maternal oriented surface and microgibbosities are described. These structures are explicable in terms of organellar hyperplasia of cortical cytoskeletal elements found in healthy tissue. Specific morphological evidence of involvement of these elements in a condition where aberrant growth control leads to the characteristic trophoblastic hyperplasia is a further indication that cytoskeletal elements may mediate transformation. An increase in resolution obtained over previous scanning electron microscope studies has allowed the description of detailed features such as 'caveolar collars' on the maternal oriented healthy and molar trophoblast surfaces. These observations are of relevance to understanding the mechanisms of several cell physiological processes, including transepithelial transport. New observations of a reticular organization in the surface layer of molar trophoblast indicate that a syncytioskeletal layer, with organization resembling that previously described in healthy chorionic villi, is also present in molar villi.

AB - The scanning ultrastructural examination of a series of 31 hydatidiform mole and 12 healthy placental specimens of similar gestational age has revealed a variety of surface architectures more common in molar tissue. Characteristic paddle-shaped sprouts, ridging of the syncytial maternal oriented surface and microgibbosities are described. These structures are explicable in terms of organellar hyperplasia of cortical cytoskeletal elements found in healthy tissue. Specific morphological evidence of involvement of these elements in a condition where aberrant growth control leads to the characteristic trophoblastic hyperplasia is a further indication that cytoskeletal elements may mediate transformation. An increase in resolution obtained over previous scanning electron microscope studies has allowed the description of detailed features such as 'caveolar collars' on the maternal oriented healthy and molar trophoblast surfaces. These observations are of relevance to understanding the mechanisms of several cell physiological processes, including transepithelial transport. New observations of a reticular organization in the surface layer of molar trophoblast indicate that a syncytioskeletal layer, with organization resembling that previously described in healthy chorionic villi, is also present in molar villi.

U2 - 10.1016/0143-4004(89)90040-4

DO - 10.1016/0143-4004(89)90040-4

M3 - Journal article

C2 - 2734255

AN - SCOPUS:0024508035

VL - 10

SP - 195

EP - 212

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - 2

ER -