TY - JOUR

T1 - Hyperalignment of motor cortical areas based on motor imagery during action observation

AU - Al-Wasity, Salim

AU - Vogt, Stefan

AU - Vuckovic, Aleksandra

AU - Pollick, Frank

PY - 2020/3/24

Y1 - 2020/3/24

N2 - Multivariate pattern Analysis (MVpA) has grown in importance due to its capacity to use both coarse and fine scale patterns of brain activity. However, a major limitation of multivariate analysis is the difficulty of aligning features across brains, which makes MVPA a subject specific analysis. Recent work by Haxby et al. (2011) introduced a method called Hyperalignment that explored neural activity in ventral temporal cortex during object recognition and demonstrated the ability to align individual patterns of brain activity into a common high dimensional space to facilitate Between Subject Classification (BSC). Here we examined BSC based on Hyperalignment of motor cortex during a task of motor imagery of three natural actions (lift, knock and throw). To achieve this we collected brain activity during the combined tasks of action observation and motor imagery to a parametric action space containing 25 stick-figure blends of the three natural actions. From these responses we derived Hyperalignment transformation parameters that were used to map subjects’ representational spaces of the motor imagery task in the motor cortex into a common model representational space. Results showed that BSC of the neural response patterns based on Hyperalignment exceeded both BSC based on anatomical alignment as well as a standard Within Subject Classification (WSC) approach. We also found that results were sensitive to the order in which participants entered the Hyperalignment algorithm. These results demonstrate the effectiveness of Hyperalignment to align neural responses across subject in motor cortex to enable BSC of motor imagery.

AB - Multivariate pattern Analysis (MVpA) has grown in importance due to its capacity to use both coarse and fine scale patterns of brain activity. However, a major limitation of multivariate analysis is the difficulty of aligning features across brains, which makes MVPA a subject specific analysis. Recent work by Haxby et al. (2011) introduced a method called Hyperalignment that explored neural activity in ventral temporal cortex during object recognition and demonstrated the ability to align individual patterns of brain activity into a common high dimensional space to facilitate Between Subject Classification (BSC). Here we examined BSC based on Hyperalignment of motor cortex during a task of motor imagery of three natural actions (lift, knock and throw). To achieve this we collected brain activity during the combined tasks of action observation and motor imagery to a parametric action space containing 25 stick-figure blends of the three natural actions. From these responses we derived Hyperalignment transformation parameters that were used to map subjects’ representational spaces of the motor imagery task in the motor cortex into a common model representational space. Results showed that BSC of the neural response patterns based on Hyperalignment exceeded both BSC based on anatomical alignment as well as a standard Within Subject Classification (WSC) approach. We also found that results were sensitive to the order in which participants entered the Hyperalignment algorithm. These results demonstrate the effectiveness of Hyperalignment to align neural responses across subject in motor cortex to enable BSC of motor imagery.

U2 - 10.1038/s41598-020-62071-2

DO - 10.1038/s41598-020-62071-2

M3 - Journal article

VL - 10

SP - 1

EP - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 10:5362

ER -