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Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study. / Shih, B.; Sultan, M.J.; Chaudhry, I.H. et al.
In: Wound Repair and Regeneration, Vol. 20, No. 5, 30.09.2012, p. 757-769.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Shih, B, Sultan, MJ, Chaudhry, IH, Tan, KT, Johal, KS, Marstan, A, Tsai, M, Baguneid, M & Bayat, A 2012, 'Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study', Wound Repair and Regeneration, vol. 20, no. 5, pp. 757-769. https://doi.org/10.1111/j.1524-475X.2012.00832.x

APA

Shih, B., Sultan, M. J., Chaudhry, I. H., Tan, K. T., Johal, K. S., Marstan, A., Tsai, M., Baguneid, M., & Bayat, A. (2012). Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study. Wound Repair and Regeneration, 20(5), 757-769. https://doi.org/10.1111/j.1524-475X.2012.00832.x

Vancouver

Shih B, Sultan MJ, Chaudhry IH, Tan KT, Johal KS, Marstan A et al. Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study. Wound Repair and Regeneration. 2012 Sept 30;20(5):757-769. Epub 2012 Sept 17. doi: 10.1111/j.1524-475X.2012.00832.x

Author

Shih, B. ; Sultan, M.J. ; Chaudhry, I.H. et al. / Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds : A genetic, histological, and noninvasive imaging study. In: Wound Repair and Regeneration. 2012 ; Vol. 20, No. 5. pp. 757-769.

Bibtex

@article{d000dca00d8646429e7ee9f437c4f16f,
title = "Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study",
abstract = "Chronic wounds are common and lead to significant patient morbidity. A better understanding of their pathogenesis and relevant biomarkers are required. We compared acute and chronic wounds in the same individual using noninvasive imaging including spectrophotometric intracutaneous analysis (SIAscopy) and full-field laser perfusion imaging. Gene expression analysis was also performed on sequential biopsies. Whole genome gene expression microarray analysis (44k), quantitative polymerase chain reaction, and immunohistochemistry were carried out to determine gene expression levels in tissue biopsies. Fifteen Caucasian patients with chronic venous ulcers had biopsies of the wound edges and simultaneously had an acute wound created on their upper arm on days 0, 7, and 14. SIAscopy revealed increased levels of melanin (p ",
author = "B. Shih and M.J. Sultan and I.H. Chaudhry and K.T. Tan and K.S. Johal and A. Marstan and M. Tsai and M. Baguneid and A. Bayat",
year = "2012",
month = sep,
day = "30",
doi = "10.1111/j.1524-475X.2012.00832.x",
language = "English",
volume = "20",
pages = "757--769",
journal = "Wound Repair and Regeneration",
issn = "1067-1927",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds

T2 - A genetic, histological, and noninvasive imaging study

AU - Shih, B.

AU - Sultan, M.J.

AU - Chaudhry, I.H.

AU - Tan, K.T.

AU - Johal, K.S.

AU - Marstan, A.

AU - Tsai, M.

AU - Baguneid, M.

AU - Bayat, A.

PY - 2012/9/30

Y1 - 2012/9/30

N2 - Chronic wounds are common and lead to significant patient morbidity. A better understanding of their pathogenesis and relevant biomarkers are required. We compared acute and chronic wounds in the same individual using noninvasive imaging including spectrophotometric intracutaneous analysis (SIAscopy) and full-field laser perfusion imaging. Gene expression analysis was also performed on sequential biopsies. Whole genome gene expression microarray analysis (44k), quantitative polymerase chain reaction, and immunohistochemistry were carried out to determine gene expression levels in tissue biopsies. Fifteen Caucasian patients with chronic venous ulcers had biopsies of the wound edges and simultaneously had an acute wound created on their upper arm on days 0, 7, and 14. SIAscopy revealed increased levels of melanin (p 

AB - Chronic wounds are common and lead to significant patient morbidity. A better understanding of their pathogenesis and relevant biomarkers are required. We compared acute and chronic wounds in the same individual using noninvasive imaging including spectrophotometric intracutaneous analysis (SIAscopy) and full-field laser perfusion imaging. Gene expression analysis was also performed on sequential biopsies. Whole genome gene expression microarray analysis (44k), quantitative polymerase chain reaction, and immunohistochemistry were carried out to determine gene expression levels in tissue biopsies. Fifteen Caucasian patients with chronic venous ulcers had biopsies of the wound edges and simultaneously had an acute wound created on their upper arm on days 0, 7, and 14. SIAscopy revealed increased levels of melanin (p 

U2 - 10.1111/j.1524-475X.2012.00832.x

DO - 10.1111/j.1524-475X.2012.00832.x

M3 - Journal article

VL - 20

SP - 757

EP - 769

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

SN - 1067-1927

IS - 5

ER -