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Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex.

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Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex. / Taylor, Elaine M.; Copsey, Alice; Hudson, Jessica et al.
In: Molecular and Cellular Biology, Vol. 28, No. 4, 15.02.2008, p. 1197-1206.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Taylor, EM, Copsey, A, Hudson, J, Vidot, S & Lehmann, A 2008, 'Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex.', Molecular and Cellular Biology, vol. 28, no. 4, pp. 1197-1206. https://doi.org/10.1128/MCB.00767-07

APA

Taylor, E. M., Copsey, A., Hudson, J., Vidot, S., & Lehmann, A. (2008). Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex. Molecular and Cellular Biology, 28(4), 1197-1206. https://doi.org/10.1128/MCB.00767-07

Vancouver

Taylor EM, Copsey A, Hudson J, Vidot S, Lehmann A. Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex. Molecular and Cellular Biology. 2008 Feb 15;28(4):1197-1206. doi: 10.1128/MCB.00767-07

Author

Taylor, Elaine M. ; Copsey, Alice ; Hudson, Jessica et al. / Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex. In: Molecular and Cellular Biology. 2008 ; Vol. 28, No. 4. pp. 1197-1206.

Bibtex

@article{226ab66e4fe64cc4abb5be825b08a9c5,
title = "Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex.",
abstract = "The SMC protein complexes play important roles in chromosome dynamics. The function of the SMC5-6 complex remains unclear, though it is involved in resolution of different DNA structures by recombination. We have now identified and characterized the four non-SMC components of the human complex and in particular demonstrated that the MAGEG1 protein is part of this complex. MAGE proteins play important but as yet undefined roles in carcinogenesis, apoptosis, and brain development. We show that, with the exception of the SUMO ligase hMMS21/hNSE2, depletion of any of the components results in degradation of all the other components. Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination.",
author = "Taylor, {Elaine M.} and Alice Copsey and Jessica Hudson and Suzanne Vidot and Alan Lehmann",
year = "2008",
month = feb,
day = "15",
doi = "10.1128/MCB.00767-07",
language = "English",
volume = "28",
pages = "1197--1206",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "4",

}

RIS

TY - JOUR

T1 - Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex.

AU - Taylor, Elaine M.

AU - Copsey, Alice

AU - Hudson, Jessica

AU - Vidot, Suzanne

AU - Lehmann, Alan

PY - 2008/2/15

Y1 - 2008/2/15

N2 - The SMC protein complexes play important roles in chromosome dynamics. The function of the SMC5-6 complex remains unclear, though it is involved in resolution of different DNA structures by recombination. We have now identified and characterized the four non-SMC components of the human complex and in particular demonstrated that the MAGEG1 protein is part of this complex. MAGE proteins play important but as yet undefined roles in carcinogenesis, apoptosis, and brain development. We show that, with the exception of the SUMO ligase hMMS21/hNSE2, depletion of any of the components results in degradation of all the other components. Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination.

AB - The SMC protein complexes play important roles in chromosome dynamics. The function of the SMC5-6 complex remains unclear, though it is involved in resolution of different DNA structures by recombination. We have now identified and characterized the four non-SMC components of the human complex and in particular demonstrated that the MAGEG1 protein is part of this complex. MAGE proteins play important but as yet undefined roles in carcinogenesis, apoptosis, and brain development. We show that, with the exception of the SUMO ligase hMMS21/hNSE2, depletion of any of the components results in degradation of all the other components. Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination.

UR - http://www.scopus.com/inward/record.url?scp=38949143250&partnerID=8YFLogxK

U2 - 10.1128/MCB.00767-07

DO - 10.1128/MCB.00767-07

M3 - Journal article

AN - SCOPUS:38949143250

VL - 28

SP - 1197

EP - 1206

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 4

ER -