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Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection

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Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection. / Staines, Henry M.; Kirwan, Daniela E.; Clark, David J. et al.
In: Emerging Infectious Diseases, Vol. 27, No. 1, 31.01.2021, p. 85-91.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Staines, HM, Kirwan, DE, Clark, DJ, Augustin, Y, Byrne, RL, Cocozza, M, Cubas-Atienzar, AI, Cuevas, LE, Cusinato, M, Davies, BMO, Davis, M, Davis, P, Duvoix, A, Eckersley, NM, Forton, D, Fraser, AJ, Garrod, G, Hadcocks, L, Hu, Q, Kay, GA, Klekotko, K, Lewis, Z, Macallan, DC, Mensah-Kane, J, Menzies, S, Monahan, I, Moore, CM, Nebe-Von-Caron, G, Owen, SI, Sainter, C, Sall, AA, Schouten, J, Williams, CT, Wilkins, J, Woolston, K, Fitchett, JRA, Krishna, S & Planche, T 2021, 'Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection', Emerging Infectious Diseases, vol. 27, no. 1, pp. 85-91. https://doi.org/10.3201/EID2701.203074

APA

Staines, H. M., Kirwan, D. E., Clark, D. J., Augustin, Y., Byrne, R. L., Cocozza, M., Cubas-Atienzar, A. I., Cuevas, L. E., Cusinato, M., Davies, B. M. O., Davis, M., Davis, P., Duvoix, A., Eckersley, N. M., Forton, D., Fraser, A. J., Garrod, G., Hadcocks, L., Hu, Q., ... Planche, T. (2021). Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection. Emerging Infectious Diseases, 27(1), 85-91. https://doi.org/10.3201/EID2701.203074

Vancouver

Staines HM, Kirwan DE, Clark DJ, Augustin Y, Byrne RL, Cocozza M et al. Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection. Emerging Infectious Diseases. 2021 Jan 31;27(1):85-91. Epub 2020 Nov 30. doi: 10.3201/EID2701.203074

Author

Staines, Henry M. ; Kirwan, Daniela E. ; Clark, David J. et al. / Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection. In: Emerging Infectious Diseases. 2021 ; Vol. 27, No. 1. pp. 85-91.

Bibtex

@article{bdb4dac29ca24da68380855c462e1afc,
title = "Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection",
abstract = "We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%-8.5% of persons did not seroconvert 3-6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.",
author = "Staines, {Henry M.} and Kirwan, {Daniela E.} and Clark, {David J.} and Yolanda Augustin and Byrne, {Rachel L.} and Michael Cocozza and Cubas-Atienzar, {Ana I.} and Cuevas, {Luis E.} and Martina Cusinato and Davies, {Benedict M.O.} and Mark Davis and Paul Davis and Annelyse Duvoix and Eckersley, {Nicholas M.} and Daniel Forton and Fraser, {Alice J.} and Gala Garrod and Linda Hadcocks and Qinxue Hu and Kay, {Grant A.} and Kesja Klekotko and Zawditu Lewis and Macallan, {Derek C.} and Josephine Mensah-Kane and Stefanie Menzies and Irene Monahan and Moore, {Catherine M.} and Gerhard Nebe-Von-Caron and Owen, {Sophie I.} and Chris Sainter and Sall, {Amadou A.} and James Schouten and Williams, {Christopher T.} and John Wilkins and Kevin Woolston and Fitchett, {Joseph R.A.} and Sanjeev Krishna and Tim Planche",
year = "2021",
month = jan,
day = "31",
doi = "10.3201/EID2701.203074",
language = "English",
volume = "27",
pages = "85--91",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "1",

}

RIS

TY - JOUR

T1 - Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection

AU - Staines, Henry M.

AU - Kirwan, Daniela E.

AU - Clark, David J.

AU - Augustin, Yolanda

AU - Byrne, Rachel L.

AU - Cocozza, Michael

AU - Cubas-Atienzar, Ana I.

AU - Cuevas, Luis E.

AU - Cusinato, Martina

AU - Davies, Benedict M.O.

AU - Davis, Mark

AU - Davis, Paul

AU - Duvoix, Annelyse

AU - Eckersley, Nicholas M.

AU - Forton, Daniel

AU - Fraser, Alice J.

AU - Garrod, Gala

AU - Hadcocks, Linda

AU - Hu, Qinxue

AU - Kay, Grant A.

AU - Klekotko, Kesja

AU - Lewis, Zawditu

AU - Macallan, Derek C.

AU - Mensah-Kane, Josephine

AU - Menzies, Stefanie

AU - Monahan, Irene

AU - Moore, Catherine M.

AU - Nebe-Von-Caron, Gerhard

AU - Owen, Sophie I.

AU - Sainter, Chris

AU - Sall, Amadou A.

AU - Schouten, James

AU - Williams, Christopher T.

AU - Wilkins, John

AU - Woolston, Kevin

AU - Fitchett, Joseph R.A.

AU - Krishna, Sanjeev

AU - Planche, Tim

PY - 2021/1/31

Y1 - 2021/1/31

N2 - We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%-8.5% of persons did not seroconvert 3-6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.

AB - We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%-8.5% of persons did not seroconvert 3-6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.

U2 - 10.3201/EID2701.203074

DO - 10.3201/EID2701.203074

M3 - Journal article

C2 - 33256890

AN - SCOPUS:85098581626

VL - 27

SP - 85

EP - 91

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 1

ER -