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Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes

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Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. / Kambris, Zakaria; Cook, Peter E.; Phuc, Hoang K. et al.
In: Science, Vol. 326, No. 5949, 02.10.2009, p. 134-136.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kambris, Z, Cook, PE, Phuc, HK & Sinkins, SP 2009, 'Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes', Science, vol. 326, no. 5949, pp. 134-136. https://doi.org/10.1126/science.1177531

APA

Kambris, Z., Cook, P. E., Phuc, H. K., & Sinkins, S. P. (2009). Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science, 326(5949), 134-136. https://doi.org/10.1126/science.1177531

Vancouver

Kambris Z, Cook PE, Phuc HK, Sinkins SP. Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science. 2009 Oct 2;326(5949):134-136. doi: 10.1126/science.1177531

Author

Kambris, Zakaria ; Cook, Peter E. ; Phuc, Hoang K. et al. / Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. In: Science. 2009 ; Vol. 326, No. 5949. pp. 134-136.

Bibtex

@article{c46681aeae5b42e38e799c6bbe107a4d,
title = "Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes",
abstract = "Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito{\textquoteright}s innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.",
author = "Zakaria Kambris and Cook, {Peter E.} and Phuc, {Hoang K.} and Sinkins, {Steven P.}",
year = "2009",
month = oct,
day = "2",
doi = "10.1126/science.1177531",
language = "English",
volume = "326",
pages = "134--136",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5949",

}

RIS

TY - JOUR

T1 - Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes

AU - Kambris, Zakaria

AU - Cook, Peter E.

AU - Phuc, Hoang K.

AU - Sinkins, Steven P.

PY - 2009/10/2

Y1 - 2009/10/2

N2 - Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito’s innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.

AB - Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito’s innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.

UR - http://www.scopus.com/inward/record.url?scp=70349664283&partnerID=8YFLogxK

U2 - 10.1126/science.1177531

DO - 10.1126/science.1177531

M3 - Journal article

AN - SCOPUS:70349664283

VL - 326

SP - 134

EP - 136

JO - Science

JF - Science

SN - 0036-8075

IS - 5949

ER -