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Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing. / Lin, Hungyen; May, Robert K.; Evans, Michael J. et al.
In: Journal of Pharmaceutical Sciences, Vol. 104, No. 8, 2015, p. 2513-2522.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lin, H, May, RK, Evans, MJ, Zhong, S, Gladden, LF, Shen, Y & Zeitler, JA 2015, 'Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing', Journal of Pharmaceutical Sciences, vol. 104, no. 8, pp. 2513-2522. https://doi.org/10.1002/jps.24503

APA

Lin, H., May, R. K., Evans, M. J., Zhong, S., Gladden, L. F., Shen, Y., & Zeitler, J. A. (2015). Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing. Journal of Pharmaceutical Sciences, 104(8), 2513-2522. https://doi.org/10.1002/jps.24503

Vancouver

Lin H, May RK, Evans MJ, Zhong S, Gladden LF, Shen Y et al. Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing. Journal of Pharmaceutical Sciences. 2015;104(8):2513-2522. doi: 10.1002/jps.24503

Author

Lin, Hungyen ; May, Robert K. ; Evans, Michael J. et al. / Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing. In: Journal of Pharmaceutical Sciences. 2015 ; Vol. 104, No. 8. pp. 2513-2522.

Bibtex

@article{f6937232d6ce472b9893b1579bd8ff3e,
title = "Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing",
abstract = "A novel in-line technique utilising pulsed terahertz radiation for direct measurement of the film coating thickness of individual tablets during the coating process was previously developed and demonstrated on a production-scale coater. Here, we use this technique to monitor the evolution of tablet film coating thickness and its inter-tablet variability during the coating process under a number of different process conditions that have been purposefully induced in the production-scale coating process. The changes that were introduced to the coating process include removing the baffles from the coater, adding uncoated tablets to the running process, halting the drum, blockage of spray guns and changes to the spray rate. The terahertz sensor was able to pick up the resulting changes in average coating thickness in the coating drum and we report the impact of these process changes on the resulting coating quality. ",
author = "Hungyen Lin and May, {Robert K.} and Evans, {Michael J.} and Shuncong Zhong and Gladden, {Lynn F.} and Yaochun Shen and Zeitler, {J. Axel}",
year = "2015",
doi = "10.1002/jps.24503",
language = "English",
volume = "104",
pages = "2513--2522",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing

AU - Lin, Hungyen

AU - May, Robert K.

AU - Evans, Michael J.

AU - Zhong, Shuncong

AU - Gladden, Lynn F.

AU - Shen, Yaochun

AU - Zeitler, J. Axel

PY - 2015

Y1 - 2015

N2 - A novel in-line technique utilising pulsed terahertz radiation for direct measurement of the film coating thickness of individual tablets during the coating process was previously developed and demonstrated on a production-scale coater. Here, we use this technique to monitor the evolution of tablet film coating thickness and its inter-tablet variability during the coating process under a number of different process conditions that have been purposefully induced in the production-scale coating process. The changes that were introduced to the coating process include removing the baffles from the coater, adding uncoated tablets to the running process, halting the drum, blockage of spray guns and changes to the spray rate. The terahertz sensor was able to pick up the resulting changes in average coating thickness in the coating drum and we report the impact of these process changes on the resulting coating quality.

AB - A novel in-line technique utilising pulsed terahertz radiation for direct measurement of the film coating thickness of individual tablets during the coating process was previously developed and demonstrated on a production-scale coater. Here, we use this technique to monitor the evolution of tablet film coating thickness and its inter-tablet variability during the coating process under a number of different process conditions that have been purposefully induced in the production-scale coating process. The changes that were introduced to the coating process include removing the baffles from the coater, adding uncoated tablets to the running process, halting the drum, blockage of spray guns and changes to the spray rate. The terahertz sensor was able to pick up the resulting changes in average coating thickness in the coating drum and we report the impact of these process changes on the resulting coating quality.

U2 - 10.1002/jps.24503

DO - 10.1002/jps.24503

M3 - Journal article

VL - 104

SP - 2513

EP - 2522

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 8

ER -