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In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

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In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. / Williams, Richard; Read, M; Timmis, J et al.
Artificial Immune Systems. ed. / Pietro Liò; Giuseppe Nicosia; Thomas Stibor . Vol. 6825 New York: Springer, 2011. p. 51-54 (Lecture Notes in Computer Science; Vol. 6825).

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

Harvard

Williams, R, Read, M, Timmis, J, Andrews, PS & Kumar, V 2011, In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. in P Liò, G Nicosia & T Stibor (eds), Artificial Immune Systems. vol. 6825, Lecture Notes in Computer Science, vol. 6825, Springer, New York, pp. 51-54. https://doi.org/10.1007/978-3-642-22371-6_5

APA

Williams, R., Read, M., Timmis, J., Andrews, P. S., & Kumar, V. (2011). In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. In P. Liò, G. Nicosia, & T. Stibor (Eds.), Artificial Immune Systems (Vol. 6825, pp. 51-54). (Lecture Notes in Computer Science; Vol. 6825). Springer. https://doi.org/10.1007/978-3-642-22371-6_5

Vancouver

Williams R, Read M, Timmis J, Andrews PS, Kumar V. In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. In Liò P, Nicosia G, Stibor T, editors, Artificial Immune Systems. Vol. 6825. New York: Springer. 2011. p. 51-54. (Lecture Notes in Computer Science). doi: 10.1007/978-3-642-22371-6_5

Author

Williams, Richard ; Read, M ; Timmis, J et al. / In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. Artificial Immune Systems. editor / Pietro Liò ; Giuseppe Nicosia ; Thomas Stibor . Vol. 6825 New York : Springer, 2011. pp. 51-54 (Lecture Notes in Computer Science).

Bibtex

@inbook{cd2f8d394799460b94d3e0d498b23edf,
title = "In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.",
author = "Richard Williams and M Read and J Timmis and Andrews, {P. S} and V Kumar",
year = "2011",
doi = "10.1007/978-3-642-22371-6_5",
language = "English",
isbn = "9783642223709",
volume = "6825",
series = "Lecture Notes in Computer Science",
publisher = "Springer",
pages = "51--54",
editor = "Pietro Li{\`o} and Giuseppe Nicosia and {Stibor }, {Thomas }",
booktitle = "Artificial Immune Systems",

}

RIS

TY - CHAP

T1 - In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

AU - Williams, Richard

AU - Read, M

AU - Timmis, J

AU - Andrews, P. S

AU - Kumar, V

PY - 2011

Y1 - 2011

N2 - Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

AB - Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

U2 - 10.1007/978-3-642-22371-6_5

DO - 10.1007/978-3-642-22371-6_5

M3 - Chapter

SN - 9783642223709

VL - 6825

T3 - Lecture Notes in Computer Science

SP - 51

EP - 54

BT - Artificial Immune Systems

A2 - Liò, Pietro

A2 - Nicosia, Giuseppe

A2 - Stibor , Thomas

PB - Springer

CY - New York

ER -