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In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

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In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications. / Leone, Federica; Firlak, Melike; Challen, Kirsty; Bonnefin, Wayne; Onida, Barbara; Wright, Karen; Hardy, John.

In: Journal of Functional Biomaterials, Vol. 10, No. 4, 50, 14.11.2019.

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Leone, Federica ; Firlak, Melike ; Challen, Kirsty ; Bonnefin, Wayne ; Onida, Barbara ; Wright, Karen ; Hardy, John. / In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications. In: Journal of Functional Biomaterials. 2019 ; Vol. 10, No. 4.

Bibtex

@article{8bae57c3afe74e6f8b267aeb23dc93ea,
title = "In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications",
abstract = "In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.",
keywords = "in situ forming, injectable, hydrogel, polysaccharide, bionanocomposite, wound healing",
author = "Federica Leone and Melike Firlak and Kirsty Challen and Wayne Bonnefin and Barbara Onida and Karen Wright and John Hardy",
year = "2019",
month = nov,
day = "14",
doi = "10.3390/jfb10040050",
language = "English",
volume = "10",
journal = "Journal of Functional Biomaterials",
issn = "2079-4983",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

AU - Leone, Federica

AU - Firlak, Melike

AU - Challen, Kirsty

AU - Bonnefin, Wayne

AU - Onida, Barbara

AU - Wright, Karen

AU - Hardy, John

PY - 2019/11/14

Y1 - 2019/11/14

N2 - In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

AB - In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

KW - in situ forming

KW - injectable

KW - hydrogel

KW - polysaccharide

KW - bionanocomposite

KW - wound healing

U2 - 10.3390/jfb10040050

DO - 10.3390/jfb10040050

M3 - Journal article

VL - 10

JO - Journal of Functional Biomaterials

JF - Journal of Functional Biomaterials

SN - 2079-4983

IS - 4

M1 - 50

ER -