This paper explores whether egg donation could still be ethically justified if in vitro gametogenesis (IVG) became reliable and safe. In order to do this, issues and concerns that might inform a patient’s reasoning in choosing to use donor eggs instead of IVG are explored and assessed. It is concluded that egg donation would only be ethically justified in a narrow range of special cases given the (hypothetical) availability of IVG treatment and, further, that egg donation could itself be replaced by donation through IVG techniques. Two possible criticisms of this position are then considered: ones based on respect for patient wishes, and loss of donor benefit. It is concluded that while neither argument constitutes a strong enough reason to continue with programmes of egg donation, egg sharing programmes could still be permitted come the advent of IVG; these could then provide a morally acceptable source of ‘natural’ donor eggs.