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In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. / Kuriyama, Sei; Theveneau, Eric; Benedetto, Alexandre et al.
In: Journal of Cell Biology, Vol. 206, No. 1, 07.07.2014, p. 113-127.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kuriyama, S, Theveneau, E, Benedetto, A, Parsons, M, Tanaka, M, Charras, G, Kabla, A & Mayor, R 2014, 'In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity', Journal of Cell Biology, vol. 206, no. 1, pp. 113-127. https://doi.org/10.1083/jcb.201402093

APA

Kuriyama, S., Theveneau, E., Benedetto, A., Parsons, M., Tanaka, M., Charras, G., Kabla, A., & Mayor, R. (2014). In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. Journal of Cell Biology, 206(1), 113-127. https://doi.org/10.1083/jcb.201402093

Vancouver

Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. Journal of Cell Biology. 2014 Jul 7;206(1):113-127. doi: 10.1083/jcb.201402093

Author

Kuriyama, Sei ; Theveneau, Eric ; Benedetto, Alexandre et al. / In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. In: Journal of Cell Biology. 2014 ; Vol. 206, No. 1. pp. 113-127.

Bibtex

@article{7b9da78611a741a5aae35096f08b4f76,
title = "In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity",
abstract = "Collective cell migration (CCM) and epithelial-mesenchymal transition (EMT) are common to cancer and morphogenesis, and are often considered to be mutually exclusive in spite of the fact that many cancer and embryonic cells that have gone through EMT still cooperate to migrate collectively. Here we use neural crest (NC) cells to address the question of how cells that have down-regulated cell-cell adhesions can migrate collectively. NC cell dissociation relies on a qualitative and quantitative change of the cadherin repertoire. We found that the level of cell-cell adhesion is precisely regulated by internalization of N-cadherin downstream of lysophosphatidic acid (LPA) receptor 2. Rather than promoting the generation of single, fully mesenchymal cells, this reduction of membrane N-cadherin only triggers a partial mesenchymal phenotype. This intermediate phenotype is characterized by an increase in tissue fluidity akin to a solid-like-to-fluid-like transition. This change of plasticity allows cells to migrate under physical constraints without abolishing cell cooperation required for collectiveness.",
keywords = "Animals, Cadherins, Cell Adhesion, Chemotaxis, Intercellular Junctions, Lysophospholipids, Neural Crest, Phosphorylation, Protein Processing, Post-Translational, Protein Transport, Receptors, Lysophosphatidic Acid, Signal Transduction, Xenopus Proteins, Xenopus laevis, Journal Article, Research Support, Non-U.S. Gov't",
author = "Sei Kuriyama and Eric Theveneau and Alexandre Benedetto and Maddy Parsons and Masamitsu Tanaka and Guillaume Charras and Alexandre Kabla and Roberto Mayor",
note = "{\textcopyright} 2014 Kuriyama et al.",
year = "2014",
month = jul,
day = "7",
doi = "10.1083/jcb.201402093",
language = "English",
volume = "206",
pages = "113--127",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "1",

}

RIS

TY - JOUR

T1 - In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

AU - Kuriyama, Sei

AU - Theveneau, Eric

AU - Benedetto, Alexandre

AU - Parsons, Maddy

AU - Tanaka, Masamitsu

AU - Charras, Guillaume

AU - Kabla, Alexandre

AU - Mayor, Roberto

N1 - © 2014 Kuriyama et al.

PY - 2014/7/7

Y1 - 2014/7/7

N2 - Collective cell migration (CCM) and epithelial-mesenchymal transition (EMT) are common to cancer and morphogenesis, and are often considered to be mutually exclusive in spite of the fact that many cancer and embryonic cells that have gone through EMT still cooperate to migrate collectively. Here we use neural crest (NC) cells to address the question of how cells that have down-regulated cell-cell adhesions can migrate collectively. NC cell dissociation relies on a qualitative and quantitative change of the cadherin repertoire. We found that the level of cell-cell adhesion is precisely regulated by internalization of N-cadherin downstream of lysophosphatidic acid (LPA) receptor 2. Rather than promoting the generation of single, fully mesenchymal cells, this reduction of membrane N-cadherin only triggers a partial mesenchymal phenotype. This intermediate phenotype is characterized by an increase in tissue fluidity akin to a solid-like-to-fluid-like transition. This change of plasticity allows cells to migrate under physical constraints without abolishing cell cooperation required for collectiveness.

AB - Collective cell migration (CCM) and epithelial-mesenchymal transition (EMT) are common to cancer and morphogenesis, and are often considered to be mutually exclusive in spite of the fact that many cancer and embryonic cells that have gone through EMT still cooperate to migrate collectively. Here we use neural crest (NC) cells to address the question of how cells that have down-regulated cell-cell adhesions can migrate collectively. NC cell dissociation relies on a qualitative and quantitative change of the cadherin repertoire. We found that the level of cell-cell adhesion is precisely regulated by internalization of N-cadherin downstream of lysophosphatidic acid (LPA) receptor 2. Rather than promoting the generation of single, fully mesenchymal cells, this reduction of membrane N-cadherin only triggers a partial mesenchymal phenotype. This intermediate phenotype is characterized by an increase in tissue fluidity akin to a solid-like-to-fluid-like transition. This change of plasticity allows cells to migrate under physical constraints without abolishing cell cooperation required for collectiveness.

KW - Animals

KW - Cadherins

KW - Cell Adhesion

KW - Chemotaxis

KW - Intercellular Junctions

KW - Lysophospholipids

KW - Neural Crest

KW - Phosphorylation

KW - Protein Processing, Post-Translational

KW - Protein Transport

KW - Receptors, Lysophosphatidic Acid

KW - Signal Transduction

KW - Xenopus Proteins

KW - Xenopus laevis

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1083/jcb.201402093

DO - 10.1083/jcb.201402093

M3 - Journal article

C2 - 25002680

VL - 206

SP - 113

EP - 127

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 1

ER -