Activity bundle (AB) simulation is a method for obtaining a specific contact network (specific to target infectious disease) from the space–time dynamics of individuals constrained both by their social activity and by the physical condition of the space. Taking advantage of AB simulation, an individual space–time activity-based model (ISTAM) is presented which integrates the infectious-disease evolution process, individual activity patterns, and stochastic infection model. ISTAM was applied to the University of Southampton in order to simulate a hypothetical influenza epidemic. The results show that the model behaviour is approximately consistent with expectations.