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Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities

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Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities. / Ma, H.; Li, J.; Wan, C. et al.

In: Environmental Science and Technology, Vol. 53, No. 7, 02.04.2019, p. 3782-3790.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Ma, H, Li, J, Wan, C, Liang, Y, Zhang, X, Dong, G, Hu, L, Yang, B, Zeng, X, Su, T, Lu, S, Chen, S, Khorram, MS, Sheng, G, Wang, X, Mai, B, Yu, Z & Zhang, G 2019, 'Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities', Environmental Science and Technology, vol. 53, no. 7, pp. 3782-3790. https://doi.org/10.1021/acs.est.8b05814

APA

Ma, H., Li, J., Wan, C., Liang, Y., Zhang, X., Dong, G., Hu, L., Yang, B., Zeng, X., Su, T., Lu, S., Chen, S., Khorram, M. S., Sheng, G., Wang, X., Mai, B., Yu, Z., & Zhang, G. (2019). Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities. Environmental Science and Technology, 53(7), 3782-3790. https://doi.org/10.1021/acs.est.8b05814

Vancouver

Ma H, Li J, Wan C, Liang Y, Zhang X, Dong G et al. Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities. Environmental Science and Technology. 2019 Apr 2;53(7):3782-3790. Epub 2019 Mar 4. doi: 10.1021/acs.est.8b05814

Author

Ma, H. ; Li, J. ; Wan, C. et al. / Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities. In: Environmental Science and Technology. 2019 ; Vol. 53, No. 7. pp. 3782-3790.

Bibtex

@article{3378160e421d4075a65e3168c902b7e2,
title = "Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities",
abstract = "Spatiotemporal trends in pro-inflammatory (interleukin (IL)-6 and IL-8) release after exposure to the water-soluble fractions of PM2.5 sampled in 10 large Chinese cities over 1 year were investigated. Chemical components (water-soluble ions, metal(loid) elements, water-soluble organic carbon (WSOC), humic-like substances (HULIS), and endotoxins) in PM2.5 samples were measured, and the molecular structure of WSOC was also analyzed by nuclear magnetic resonance. Changes in DNA methylation and gene expression of candidate genes were also evaluated to explore the potential mechanisms. PM2.5 from southern cities induced lower pro-inflammatory responses compared to those from northern cities. Seasonal differences in toxicity were noted among the cities. IL-6 was significantly correlated with HULIS (as the main fraction of WSOC with oxygenated carbohydrate structures characteristic), Pb, and endotoxin. Furthermore, DNA methylation and gene expression changes in RASSF2 and CYPIB1 were related to pro inflammatory secretion. Certain components of PM25, rather than PM2.5 mass itself, determine the pro-inflammatory release. In particular, HULIS, which originated from primary biomass burning and residual coal combustion, and secondary organic aerosols, appear to be the key component in PM2.5 to induce human health risk.",
keywords = "Alkylation, Chemical analysis, Gene expression, Health risks, Lead compounds, Methylation, Organic carbon, Humic-like substances, Inflammatory response, Potential mechanism, Seasonal differences, Secondary organic aerosols, Spatiotemporal trends, Water soluble fraction, Water-soluble organic carbon, Coal combustion",
author = "H. Ma and J. Li and C. Wan and Y. Liang and X. Zhang and G. Dong and L. Hu and B. Yang and X. Zeng and T. Su and S. Lu and S. Chen and M.S. Khorram and G. Sheng and X. Wang and B. Mai and Z. Yu and G. Zhang",
note = "This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright {\textcopyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.est.8b05814",
year = "2019",
month = apr,
day = "2",
doi = "10.1021/acs.est.8b05814",
language = "English",
volume = "53",
pages = "3782--3790",
journal = "Environmental Science and Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "7",

}

RIS

TY - JOUR

T1 - Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities

AU - Ma, H.

AU - Li, J.

AU - Wan, C.

AU - Liang, Y.

AU - Zhang, X.

AU - Dong, G.

AU - Hu, L.

AU - Yang, B.

AU - Zeng, X.

AU - Su, T.

AU - Lu, S.

AU - Chen, S.

AU - Khorram, M.S.

AU - Sheng, G.

AU - Wang, X.

AU - Mai, B.

AU - Yu, Z.

AU - Zhang, G.

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.est.8b05814

PY - 2019/4/2

Y1 - 2019/4/2

N2 - Spatiotemporal trends in pro-inflammatory (interleukin (IL)-6 and IL-8) release after exposure to the water-soluble fractions of PM2.5 sampled in 10 large Chinese cities over 1 year were investigated. Chemical components (water-soluble ions, metal(loid) elements, water-soluble organic carbon (WSOC), humic-like substances (HULIS), and endotoxins) in PM2.5 samples were measured, and the molecular structure of WSOC was also analyzed by nuclear magnetic resonance. Changes in DNA methylation and gene expression of candidate genes were also evaluated to explore the potential mechanisms. PM2.5 from southern cities induced lower pro-inflammatory responses compared to those from northern cities. Seasonal differences in toxicity were noted among the cities. IL-6 was significantly correlated with HULIS (as the main fraction of WSOC with oxygenated carbohydrate structures characteristic), Pb, and endotoxin. Furthermore, DNA methylation and gene expression changes in RASSF2 and CYPIB1 were related to pro inflammatory secretion. Certain components of PM25, rather than PM2.5 mass itself, determine the pro-inflammatory release. In particular, HULIS, which originated from primary biomass burning and residual coal combustion, and secondary organic aerosols, appear to be the key component in PM2.5 to induce human health risk.

AB - Spatiotemporal trends in pro-inflammatory (interleukin (IL)-6 and IL-8) release after exposure to the water-soluble fractions of PM2.5 sampled in 10 large Chinese cities over 1 year were investigated. Chemical components (water-soluble ions, metal(loid) elements, water-soluble organic carbon (WSOC), humic-like substances (HULIS), and endotoxins) in PM2.5 samples were measured, and the molecular structure of WSOC was also analyzed by nuclear magnetic resonance. Changes in DNA methylation and gene expression of candidate genes were also evaluated to explore the potential mechanisms. PM2.5 from southern cities induced lower pro-inflammatory responses compared to those from northern cities. Seasonal differences in toxicity were noted among the cities. IL-6 was significantly correlated with HULIS (as the main fraction of WSOC with oxygenated carbohydrate structures characteristic), Pb, and endotoxin. Furthermore, DNA methylation and gene expression changes in RASSF2 and CYPIB1 were related to pro inflammatory secretion. Certain components of PM25, rather than PM2.5 mass itself, determine the pro-inflammatory release. In particular, HULIS, which originated from primary biomass burning and residual coal combustion, and secondary organic aerosols, appear to be the key component in PM2.5 to induce human health risk.

KW - Alkylation

KW - Chemical analysis

KW - Gene expression

KW - Health risks

KW - Lead compounds

KW - Methylation

KW - Organic carbon

KW - Humic-like substances

KW - Inflammatory response

KW - Potential mechanism

KW - Seasonal differences

KW - Secondary organic aerosols

KW - Spatiotemporal trends

KW - Water soluble fraction

KW - Water-soluble organic carbon

KW - Coal combustion

U2 - 10.1021/acs.est.8b05814

DO - 10.1021/acs.est.8b05814

M3 - Journal article

VL - 53

SP - 3782

EP - 3790

JO - Environmental Science and Technology

JF - Environmental Science and Technology

SN - 0013-936X

IS - 7

ER -