Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Influence of processing parameters and solid concentration on microstructural properties of gel-casted porous hydroxyapatite
AU - Asif, A.
AU - Nazir, R.
AU - Riaz, T.
AU - Ashraf, N.
AU - Zahid, S.
AU - Shahid, R.
AU - Ur-Rehman, A.
AU - Chaudhry, A.A.
AU - Ur Rehman, I.
PY - 2014
Y1 - 2014
N2 - Porous hydroxyapatite (HA) scaffolds with interconnected porosity have been successfully fabricated by using food grade gelatin as a gelling agent. Phase stability, chemical composition and topographical features of HA scaffolds were evaluated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy and scanning electron microscopy respectively. XRD study revealed that additives used in the gel-casting process did not influence the phase composition of the investigated materials. The porosity of sintered scaffolds was assessed by the liquid displacement method and found to be 55-76 %. The pores were tailored to spherical shape and size in the range 300-400 nm, feature of utmost interest to clinicians for cell attachment, proliferation and development of soft tissues. Biocompatibility of HA scaffolds was evaluated via hemolysis studies. The results of hemolysis proved the highly biocompatible behavior of the synthesized HA scaffolds. © 2013 Springer Science+Business Media New York.
AB - Porous hydroxyapatite (HA) scaffolds with interconnected porosity have been successfully fabricated by using food grade gelatin as a gelling agent. Phase stability, chemical composition and topographical features of HA scaffolds were evaluated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy and scanning electron microscopy respectively. XRD study revealed that additives used in the gel-casting process did not influence the phase composition of the investigated materials. The porosity of sintered scaffolds was assessed by the liquid displacement method and found to be 55-76 %. The pores were tailored to spherical shape and size in the range 300-400 nm, feature of utmost interest to clinicians for cell attachment, proliferation and development of soft tissues. Biocompatibility of HA scaffolds was evaluated via hemolysis studies. The results of hemolysis proved the highly biocompatible behavior of the synthesized HA scaffolds. © 2013 Springer Science+Business Media New York.
KW - Biocompatibility
KW - Gel-casting
KW - Hydroxyapatite
KW - Interconnected porosity
KW - Porous scaffolds
KW - Chemical compositions
KW - Micro-structural properties
KW - Porous hydroxyapatite
KW - Porous scaffold
KW - Processing parameters
KW - Topographical features
KW - Blood
KW - Casting
KW - Fourier transform infrared spectroscopy
KW - Porosity
KW - Scanning electron microscopy
KW - Sintering
KW - X ray diffraction
KW - Scaffolds (biology)
U2 - 10.1007/s10934-013-9743-x
DO - 10.1007/s10934-013-9743-x
M3 - Journal article
VL - 21
SP - 31
EP - 37
JO - Journal of Porous Materials
JF - Journal of Porous Materials
SN - 1380-2224
IS - 1
ER -