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Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress

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Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress. / Shih, B.B.; Farrar, M.D.; Vail, A. et al.
In: Free Radical Biology and Medicine, Vol. 160, 20.11.2020, p. 40-46.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Shih, BB, Farrar, MD, Vail, A, Allan, D, Chao, M-R, Hu, C-W, Jones, GDD, Cooke, MS & Rhodes, LE 2020, 'Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress', Free Radical Biology and Medicine, vol. 160, pp. 40-46. https://doi.org/10.1016/j.freeradbiomed.2020.07.034

APA

Shih, B. B., Farrar, M. D., Vail, A., Allan, D., Chao, M-R., Hu, C-W., Jones, G. D. D., Cooke, M. S., & Rhodes, L. E. (2020). Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress. Free Radical Biology and Medicine, 160, 40-46. https://doi.org/10.1016/j.freeradbiomed.2020.07.034

Vancouver

Shih BB, Farrar MD, Vail A, Allan D, Chao M-R, Hu C-W et al. Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress. Free Radical Biology and Medicine. 2020 Nov 20;160:40-46. Epub 2020 Aug 15. doi: 10.1016/j.freeradbiomed.2020.07.034

Author

Shih, B.B. ; Farrar, M.D. ; Vail, A. et al. / Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress. In: Free Radical Biology and Medicine. 2020 ; Vol. 160. pp. 40-46.

Bibtex

@article{3332664e4af645d598b5416a41f5362a,
title = "Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress",
abstract = "Skin melanisation ranges widely across human populations. Melanin has antioxidant properties and also acts as a filter to solar ultraviolet radiation (UVR) incident upon the skin. In this study we firstly examined whether melanin level might influence baseline levels of systemic oxidative stress, in 65 humans in vivo from the same geographical area ranging from the lightest to darkest skin type (phototype I-VI). This was examined in winter-time (latitude 53.5°N). Remarkably, we found that urinary biomarkers of oxidatively-generated DNA damage (8-oxodG) and RNA damage (8-oxoGuo) were significantly correlated with skin lightness (L*), such that 14-15% of the variation in their baseline levels could be explained by skin colour. Next we exposed 15 humans at the extremes of skin melanisation to a simulated summer-time exposure of solar UVR (95% UVA, 5% UVB; dose standardised to sunburn threshold), following which they provided a sample of every urine void over the next five days. We found that UVR induced a small but significant increase in urinary 8-oxodG and 8-oxoGuo, with differing kinetics between skin types. Thus greater melanisation is associated with protection against systemic oxidative stress, which may reflect melanin's antioxidant properties, and solar UVR exposure also influences systemic oxidative stress levels in humans. These novel findings may have profound implications for human physiology and health.",
keywords = "Oxidative stress, Melanin, Skin, Ultraviolet radiation, Nucleic acids, Biomarkers",
author = "B.B. Shih and M.D. Farrar and A. Vail and D. Allan and M.-R. Chao and C.-W. Hu and G.D.D. Jones and M.S. Cooke and L.E. Rhodes",
year = "2020",
month = nov,
day = "20",
doi = "10.1016/j.freeradbiomed.2020.07.034",
language = "English",
volume = "160",
pages = "40--46",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "ELSEVIER SCIENCE INC",

}

RIS

TY - JOUR

T1 - Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress

AU - Shih, B.B.

AU - Farrar, M.D.

AU - Vail, A.

AU - Allan, D.

AU - Chao, M.-R.

AU - Hu, C.-W.

AU - Jones, G.D.D.

AU - Cooke, M.S.

AU - Rhodes, L.E.

PY - 2020/11/20

Y1 - 2020/11/20

N2 - Skin melanisation ranges widely across human populations. Melanin has antioxidant properties and also acts as a filter to solar ultraviolet radiation (UVR) incident upon the skin. In this study we firstly examined whether melanin level might influence baseline levels of systemic oxidative stress, in 65 humans in vivo from the same geographical area ranging from the lightest to darkest skin type (phototype I-VI). This was examined in winter-time (latitude 53.5°N). Remarkably, we found that urinary biomarkers of oxidatively-generated DNA damage (8-oxodG) and RNA damage (8-oxoGuo) were significantly correlated with skin lightness (L*), such that 14-15% of the variation in their baseline levels could be explained by skin colour. Next we exposed 15 humans at the extremes of skin melanisation to a simulated summer-time exposure of solar UVR (95% UVA, 5% UVB; dose standardised to sunburn threshold), following which they provided a sample of every urine void over the next five days. We found that UVR induced a small but significant increase in urinary 8-oxodG and 8-oxoGuo, with differing kinetics between skin types. Thus greater melanisation is associated with protection against systemic oxidative stress, which may reflect melanin's antioxidant properties, and solar UVR exposure also influences systemic oxidative stress levels in humans. These novel findings may have profound implications for human physiology and health.

AB - Skin melanisation ranges widely across human populations. Melanin has antioxidant properties and also acts as a filter to solar ultraviolet radiation (UVR) incident upon the skin. In this study we firstly examined whether melanin level might influence baseline levels of systemic oxidative stress, in 65 humans in vivo from the same geographical area ranging from the lightest to darkest skin type (phototype I-VI). This was examined in winter-time (latitude 53.5°N). Remarkably, we found that urinary biomarkers of oxidatively-generated DNA damage (8-oxodG) and RNA damage (8-oxoGuo) were significantly correlated with skin lightness (L*), such that 14-15% of the variation in their baseline levels could be explained by skin colour. Next we exposed 15 humans at the extremes of skin melanisation to a simulated summer-time exposure of solar UVR (95% UVA, 5% UVB; dose standardised to sunburn threshold), following which they provided a sample of every urine void over the next five days. We found that UVR induced a small but significant increase in urinary 8-oxodG and 8-oxoGuo, with differing kinetics between skin types. Thus greater melanisation is associated with protection against systemic oxidative stress, which may reflect melanin's antioxidant properties, and solar UVR exposure also influences systemic oxidative stress levels in humans. These novel findings may have profound implications for human physiology and health.

KW - Oxidative stress

KW - Melanin

KW - Skin

KW - Ultraviolet radiation

KW - Nucleic acids

KW - Biomarkers

U2 - 10.1016/j.freeradbiomed.2020.07.034

DO - 10.1016/j.freeradbiomed.2020.07.034

M3 - Journal article

C2 - 32768566

VL - 160

SP - 40

EP - 46

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

ER -