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Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer

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Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer. / Ramirez, Carlos A. Meza; Stringfellow, Helen; Naik, Raj et al.
In: Cancers, Vol. 14, No. 20, 5015, 13.10.2022.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Ramirez CAM, Stringfellow H, Naik R, Crosbie EJ, Paraskevaidi M, Rehman IU et al. Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer. Cancers. 2022 Oct 13;14(20):5015. doi: 10.3390/cancers14205015

Author

Ramirez, Carlos A. Meza ; Stringfellow, Helen ; Naik, Raj et al. / Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer. In: Cancers. 2022 ; Vol. 14, No. 20.

Bibtex

@article{f7c6ab1f5b684f819306e4064d87908e,
title = "Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer",
abstract = "Current triage for women with post-menopausal bleeding (PMB) to diagnose endometrial cancer rely on specialist referral for intimate tests to sequentially image, visualise and sample the endometrium. A point-of-care non-invasive triage tool with an instant readout could provide immediate reassurance for low-risk symptomatic women, whilst fast-tracking high-risk women for urgent intrauterine investigations. This study assessed the potential for infrared (IR) spectroscopy and attenuated total reflection (ATR) technology coupled with chemometric analysis of the resulting spectra for endometrial cancer detection in urine samples. Standardised urine collection and processing protocols were developed to ensure spectroscopic differences between cases and controls reflected cancer status. Urine spectroscopy distinguished endometrial cancer (n = 109) from benign gynaecological conditions (n = 110) with a sensitivity of 98% and specificity of 97%. If confirmed in subsequent low prevalence studies embedded in PMB clinics, this novel endometrial cancer detection tool could transform clinical practice by accurately selecting women with malignant pathology for urgent diagnostic work up whilst safely reassuring those without.",
keywords = "Cancer Research, Oncology",
author = "Ramirez, {Carlos A. Meza} and Helen Stringfellow and Raj Naik and Crosbie, {Emma J.} and Maria Paraskevaidi and Rehman, {Ihtesham U.} and Pierre Martin-Hirsch",
year = "2022",
month = oct,
day = "13",
doi = "10.3390/cancers14205015",
language = "English",
volume = "14",
journal = "Cancers",
issn = "2072-6694",
publisher = "MDPI",
number = "20",

}

RIS

TY - JOUR

T1 - Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer

AU - Ramirez, Carlos A. Meza

AU - Stringfellow, Helen

AU - Naik, Raj

AU - Crosbie, Emma J.

AU - Paraskevaidi, Maria

AU - Rehman, Ihtesham U.

AU - Martin-Hirsch, Pierre

PY - 2022/10/13

Y1 - 2022/10/13

N2 - Current triage for women with post-menopausal bleeding (PMB) to diagnose endometrial cancer rely on specialist referral for intimate tests to sequentially image, visualise and sample the endometrium. A point-of-care non-invasive triage tool with an instant readout could provide immediate reassurance for low-risk symptomatic women, whilst fast-tracking high-risk women for urgent intrauterine investigations. This study assessed the potential for infrared (IR) spectroscopy and attenuated total reflection (ATR) technology coupled with chemometric analysis of the resulting spectra for endometrial cancer detection in urine samples. Standardised urine collection and processing protocols were developed to ensure spectroscopic differences between cases and controls reflected cancer status. Urine spectroscopy distinguished endometrial cancer (n = 109) from benign gynaecological conditions (n = 110) with a sensitivity of 98% and specificity of 97%. If confirmed in subsequent low prevalence studies embedded in PMB clinics, this novel endometrial cancer detection tool could transform clinical practice by accurately selecting women with malignant pathology for urgent diagnostic work up whilst safely reassuring those without.

AB - Current triage for women with post-menopausal bleeding (PMB) to diagnose endometrial cancer rely on specialist referral for intimate tests to sequentially image, visualise and sample the endometrium. A point-of-care non-invasive triage tool with an instant readout could provide immediate reassurance for low-risk symptomatic women, whilst fast-tracking high-risk women for urgent intrauterine investigations. This study assessed the potential for infrared (IR) spectroscopy and attenuated total reflection (ATR) technology coupled with chemometric analysis of the resulting spectra for endometrial cancer detection in urine samples. Standardised urine collection and processing protocols were developed to ensure spectroscopic differences between cases and controls reflected cancer status. Urine spectroscopy distinguished endometrial cancer (n = 109) from benign gynaecological conditions (n = 110) with a sensitivity of 98% and specificity of 97%. If confirmed in subsequent low prevalence studies embedded in PMB clinics, this novel endometrial cancer detection tool could transform clinical practice by accurately selecting women with malignant pathology for urgent diagnostic work up whilst safely reassuring those without.

KW - Cancer Research

KW - Oncology

U2 - 10.3390/cancers14205015

DO - 10.3390/cancers14205015

M3 - Journal article

VL - 14

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 20

M1 - 5015

ER -