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Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity. / Ruiz de Almodovar, J. M.; Nunez, M. I.; McMillan, T. J. et al.
In: British Journal of Cancer, Vol. 69, No. 3, 03.1994, p. 457-462.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Ruiz de Almodovar, JM, Nunez, MI, McMillan, TJ, Olea, N, Mort, C, Villalobos, M, Pedraza, V & Steel, GG 1994, 'Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity.', British Journal of Cancer, vol. 69, no. 3, pp. 457-462. https://doi.org/10.1038/bjc.1994.83

APA

Ruiz de Almodovar, J. M., Nunez, M. I., McMillan, T. J., Olea, N., Mort, C., Villalobos, M., Pedraza, V., & Steel, G. G. (1994). Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity. British Journal of Cancer, 69(3), 457-462. https://doi.org/10.1038/bjc.1994.83

Vancouver

Ruiz de Almodovar JM, Nunez MI, McMillan TJ, Olea N, Mort C, Villalobos M et al. Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity. British Journal of Cancer. 1994 Mar;69(3):457-462. doi: 10.1038/bjc.1994.83

Author

Ruiz de Almodovar, J. M. ; Nunez, M. I. ; McMillan, T. J. et al. / Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity. In: British Journal of Cancer. 1994 ; Vol. 69, No. 3. pp. 457-462.

Bibtex

@article{d893c39dad14467bb2377120ef827809,
title = "Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity.",
abstract = "The role of the initial DNA double-strand breaks (dsb) as a determinant of cellular radiosensitivity was studied in human breast and bladder cancer cell lines. Cell survival was measured by monolayer colony-forming assay as appropriate and differences in radiosensitivity were seen (alpha-values ranged from 0.12 to 0.54). After pulsed-field gel electrophoresis (PFGE) the initial slopes of dose-response curves were biphasic with a flattening of the curves above 30 Gy. When the frequency of DNA dsb induction was assessed using a mathematical model based on the DNA fragment size distribution into the gel lane, we found a statistically significant relationship between the number of DNA dsb induced and the corresponding alpha-values and fraction surviving after 2Gy (P = 0.0049 and P = 0.0031 respectively). These results support the view that initial damage is a major determinant of cell radiosensitivity.",
author = "{Ruiz de Almodovar}, {J. M.} and Nunez, {M. I.} and McMillan, {T. J.} and N. Olea and C. Mort and M. Villalobos and V. Pedraza and Steel, {G. G.}",
year = "1994",
month = mar,
doi = "10.1038/bjc.1994.83",
language = "English",
volume = "69",
pages = "457--462",
journal = "British Journal of Cancer",
issn = "1532-1827",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - Initial radiation-induced DNA damage in human tumour cell lines : a correlation with intrinsic radiosensitivity.

AU - Ruiz de Almodovar, J. M.

AU - Nunez, M. I.

AU - McMillan, T. J.

AU - Olea, N.

AU - Mort, C.

AU - Villalobos, M.

AU - Pedraza, V.

AU - Steel, G. G.

PY - 1994/3

Y1 - 1994/3

N2 - The role of the initial DNA double-strand breaks (dsb) as a determinant of cellular radiosensitivity was studied in human breast and bladder cancer cell lines. Cell survival was measured by monolayer colony-forming assay as appropriate and differences in radiosensitivity were seen (alpha-values ranged from 0.12 to 0.54). After pulsed-field gel electrophoresis (PFGE) the initial slopes of dose-response curves were biphasic with a flattening of the curves above 30 Gy. When the frequency of DNA dsb induction was assessed using a mathematical model based on the DNA fragment size distribution into the gel lane, we found a statistically significant relationship between the number of DNA dsb induced and the corresponding alpha-values and fraction surviving after 2Gy (P = 0.0049 and P = 0.0031 respectively). These results support the view that initial damage is a major determinant of cell radiosensitivity.

AB - The role of the initial DNA double-strand breaks (dsb) as a determinant of cellular radiosensitivity was studied in human breast and bladder cancer cell lines. Cell survival was measured by monolayer colony-forming assay as appropriate and differences in radiosensitivity were seen (alpha-values ranged from 0.12 to 0.54). After pulsed-field gel electrophoresis (PFGE) the initial slopes of dose-response curves were biphasic with a flattening of the curves above 30 Gy. When the frequency of DNA dsb induction was assessed using a mathematical model based on the DNA fragment size distribution into the gel lane, we found a statistically significant relationship between the number of DNA dsb induced and the corresponding alpha-values and fraction surviving after 2Gy (P = 0.0049 and P = 0.0031 respectively). These results support the view that initial damage is a major determinant of cell radiosensitivity.

U2 - 10.1038/bjc.1994.83

DO - 10.1038/bjc.1994.83

M3 - Journal article

VL - 69

SP - 457

EP - 462

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 1532-1827

IS - 3

ER -