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Innate DNA sensing moves to the nucleus

Research output: Contribution to journalJournal articlepeer-review

<mark>Journal publication date</mark>19/05/2011
<mark>Journal</mark>Cell Host and Microbe
Issue number5
Number of pages3
Pages (from-to)351-353
Publication StatusPublished
<mark>Original language</mark>English


It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.