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Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4

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Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4. / Olmo, Roenick P.; Todjro, Yaovi M. H.; Aguiar, Eric R. G. R. et al.
In: Biorxiv, 05.06.2021, p. 2021.06.05.447047.

Research output: Contribution to Journal/Magazine › Journal article

Harvard

Olmo, RP, Todjro, YMH, Aguiar, ERGR, de Almeida, JPP, Armache, JN, de Faria, IJS, Ferreira, FV, Silva, ATS, de Souza, KPR, Vilela, APP, Tan, CH, Diallo, M, Gaye, A, Paupy, C, Obame-Nkoghe, J, Visser, TM, Koenraadt, CJM, Wongsokarijo, MA, Cruz, ALC, Prieto, MT, Parra, MCP, Nogueira, ML, Avelino-Silva, V, Mota, RN, Borges, MAZ, Drumond, BP, Kroon, EG, Sedda, L, Marois, E, Imler, J-L & Marques, JT 2021, 'Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4', Biorxiv, pp. 2021.06.05.447047. https://doi.org/10.1101/2021.06.05.447047

APA

Olmo, R. P., Todjro, Y. M. H., Aguiar, E. R. G. R., de Almeida, J. P. P., Armache, J. N., de Faria, I. J. S., Ferreira, F. V., Silva, A. T. S., de Souza, K. P. R., Vilela, A. P. P., Tan, C. H., Diallo, M., Gaye, A., Paupy, C., Obame-Nkoghe, J., Visser, T. M., Koenraadt, C. J. M., Wongsokarijo, M. A., Cruz, A. L. C., ... Marques, J. T. (2021). Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4. Biorxiv, 2021.06.05.447047. https://doi.org/10.1101/2021.06.05.447047

Vancouver

Olmo RP, Todjro YMH, Aguiar ERGR, de Almeida JPP, Armache JN, de Faria IJS et al. Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4. Biorxiv. 2021 Jun 5;2021.06.05.447047. doi: 10.1101/2021.06.05.447047

Author

Olmo, Roenick P. ; Todjro, Yaovi M. H. ; Aguiar, Eric R. G. R. et al. / Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4. In: Biorxiv. 2021 ; pp. 2021.06.05.447047.

Bibtex

@article{25f21b2005f149d7b8d4f06268dbd881,
title = "Insect-specific viruses regulate vector competence in Aedes aegypti mosquitoes via expression of histone H4",
abstract = "Aedes aegypti and Aedes albopictus are major mosquito vectors for arthropod-borne viruses (arboviruses) such as dengue (DENV) and Zika (ZIKV) viruses. Mosquitoes also carry insect-specific viruses (ISVs) that may affect the transmission of arboviruses. Here, we analyzed the global virome in urban Aedes mosquitoes and observed that two insect-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most prevalent in A. aegypti worldwide except for African cities, where transmission of arboviruses is low. Spatiotemporal analysis revealed that presence of HTV and PCLV led to a 200% increase in the chances of having DENV in wild mosquitoes. In the laboratory, we showed that HTV and PCLV prevented downregulation of histone H4, a previously unrecognized proviral host factor, and rendered mosquitoes more susceptible to DENV and ZIKV. Altogether, our data reveals a molecular basis for the regulation of A. aegypti vector competence by highly prevalent ISVs that may impact how we analyze the risk of arbovirus outbreaks. ",
author = "Olmo, {Roenick P.} and Todjro, {Yaovi M. H.} and Aguiar, {Eric R. G. R.} and {de Almeida}, {Jo{\~a}o Paulo P.} and Armache, {Juliana N.} and {de Faria}, {Isaque J. S.} and Ferreira, {Fl{\'a}via V.} and Silva, {Ana Teresa S.} and {de Souza}, {K{\'a}tia P. R.} and Vilela, {Ana Paula P.} and Tan, {Cheong H.} and Mawlouth Diallo and Alioune Gaye and Christophe Paupy and Judica{\"e}l Obame-Nkoghe and Visser, {Tessa M.} and Koenraadt, {Constantianus J. M.} and Wongsokarijo, {Merril A.} and Cruz, {Ana Luiza C.} and Prieto, {Mariliza T.} and Parra, {Maisa C. P.} and Nogueira, {Maur{\'i}cio L.} and Vivian Avelino-Silva and Mota, {Renato N.} and Borges, {Magno A. Z.} and Drumond, {Bet{\^a}nia P.} and Kroon, {Erna G.} and Luigi Sedda and Eric Marois and Jean-Luc Imler and Marques, {Jo{\~a}o T.}",
year = "2021",
month = jun,
day = "5",
doi = "10.1101/2021.06.05.447047",
language = "English",
pages = "2021.06.05.447047",
journal = "Biorxiv",
publisher = "Cold Spring Harbor Laboratory Press",

}

RIS

TY - JOUR

T1 - Insect-specific viruses regulate vector competence in Aedes aegypti mosquitoes via expression of histone H4

AU - Olmo, Roenick P.

AU - Todjro, Yaovi M. H.

AU - Aguiar, Eric R. G. R.

AU - de Almeida, João Paulo P.

AU - Armache, Juliana N.

AU - de Faria, Isaque J. S.

AU - Ferreira, Flávia V.

AU - Silva, Ana Teresa S.

AU - de Souza, Kátia P. R.

AU - Vilela, Ana Paula P.

AU - Tan, Cheong H.

AU - Diallo, Mawlouth

AU - Gaye, Alioune

AU - Paupy, Christophe

AU - Obame-Nkoghe, Judicaël

AU - Visser, Tessa M.

AU - Koenraadt, Constantianus J. M.

AU - Wongsokarijo, Merril A.

AU - Cruz, Ana Luiza C.

AU - Prieto, Mariliza T.

AU - Parra, Maisa C. P.

AU - Nogueira, Maurício L.

AU - Avelino-Silva, Vivian

AU - Mota, Renato N.

AU - Borges, Magno A. Z.

AU - Drumond, Betânia P.

AU - Kroon, Erna G.

AU - Sedda, Luigi

AU - Marois, Eric

AU - Imler, Jean-Luc

AU - Marques, João T.

PY - 2021/6/5

Y1 - 2021/6/5

N2 - Aedes aegypti and Aedes albopictus are major mosquito vectors for arthropod-borne viruses (arboviruses) such as dengue (DENV) and Zika (ZIKV) viruses. Mosquitoes also carry insect-specific viruses (ISVs) that may affect the transmission of arboviruses. Here, we analyzed the global virome in urban Aedes mosquitoes and observed that two insect-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most prevalent in A. aegypti worldwide except for African cities, where transmission of arboviruses is low. Spatiotemporal analysis revealed that presence of HTV and PCLV led to a 200% increase in the chances of having DENV in wild mosquitoes. In the laboratory, we showed that HTV and PCLV prevented downregulation of histone H4, a previously unrecognized proviral host factor, and rendered mosquitoes more susceptible to DENV and ZIKV. Altogether, our data reveals a molecular basis for the regulation of A. aegypti vector competence by highly prevalent ISVs that may impact how we analyze the risk of arbovirus outbreaks.

AB - Aedes aegypti and Aedes albopictus are major mosquito vectors for arthropod-borne viruses (arboviruses) such as dengue (DENV) and Zika (ZIKV) viruses. Mosquitoes also carry insect-specific viruses (ISVs) that may affect the transmission of arboviruses. Here, we analyzed the global virome in urban Aedes mosquitoes and observed that two insect-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most prevalent in A. aegypti worldwide except for African cities, where transmission of arboviruses is low. Spatiotemporal analysis revealed that presence of HTV and PCLV led to a 200% increase in the chances of having DENV in wild mosquitoes. In the laboratory, we showed that HTV and PCLV prevented downregulation of histone H4, a previously unrecognized proviral host factor, and rendered mosquitoes more susceptible to DENV and ZIKV. Altogether, our data reveals a molecular basis for the regulation of A. aegypti vector competence by highly prevalent ISVs that may impact how we analyze the risk of arbovirus outbreaks.

U2 - 10.1101/2021.06.05.447047

DO - 10.1101/2021.06.05.447047

M3 - Journal article

SP - 2021.06.05.447047

JO - Biorxiv

JF - Biorxiv

ER -