Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease
AU - Laansma, M.A.
AU - Bright, J.K.
AU - Al-Bachari, S.
AU - Anderson, T.J.
AU - Ard, T.
AU - Assogna, F.
AU - Baquero, K.A.
AU - Berendse, H.W.
AU - Blair, J.
AU - Cendes, F.
AU - Dalrymple-Alford, J.C.
AU - de Bie, R.M.A.
AU - Debove, I.
AU - Dirkx, M.F.
AU - Druzgal, J.
AU - Emsley, H.C.A.
AU - Garraux, G.
AU - Guimarães, R.P.
AU - Gutman, B.A.
AU - Helmich, R.C.
AU - Klein, J.C.
AU - Mackay, C.E.
AU - McMillan, C.T.
AU - Melzer, T.R.
AU - Parkes, L.M.
AU - Piras, F.
AU - Pitcher, T.L.
AU - Poston, K.L.
AU - Rango, M.
AU - Ribeiro, L.F.
AU - Rocha, C.S.
AU - Rummel, C.
AU - Santos, L.S.R.
AU - Schmidt, R.
AU - Schwingenschuh, P.
AU - Spalletta, G.
AU - Squarcina, L.
AU - van den Heuvel, O.A.
AU - Vriend, C.
AU - Wang, J.-J.
AU - Weintraub, D.
AU - Wiest, R.
AU - Yasuda, C.L.
AU - Jahanshad, N.
AU - Thompson, P.M.
AU - van der Werf, Y.D.
AU - Study, The ENIGMA-Parkinson's
PY - 2021/11/30
Y1 - 2021/11/30
N2 - Background: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. Methods: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. Results: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax = −0.20, dmin = −0.09). The bilateral putamen (dleft = −0.14, dright = −0.14) and left amygdala (d = −0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. Conclusions: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations.
AB - Background: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. Methods: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. Results: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax = −0.20, dmin = −0.09). The bilateral putamen (dleft = −0.14, dright = −0.14) and left amygdala (d = −0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. Conclusions: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations.
KW - brain
KW - disease severity
KW - ENIGMA
KW - MRI
KW - Parkinson's disease
U2 - 10.1002/mds.28706
DO - 10.1002/mds.28706
M3 - Journal article
VL - 36
SP - 2583
EP - 2594
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 11
ER -