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    Rights statement: This is the author’s version of a work that was accepted for publication in Psychoneuroendocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychoneuroendocrinology, 132, 2021 DOI: 10.1016/j.psyneuen.2021.105352

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Intranasal oxytocin, testosterone reactivity, and human competitiveness

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Intranasal oxytocin, testosterone reactivity, and human competitiveness. / Cherki, B.R.; Winter, E.; Mankuta, D. et al.
In: Psychoneuroendocrinology, Vol. 132, 105352, 31.10.2021.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Cherki, BR, Winter, E, Mankuta, D & Israel, S 2021, 'Intranasal oxytocin, testosterone reactivity, and human competitiveness', Psychoneuroendocrinology, vol. 132, 105352. https://doi.org/10.1016/j.psyneuen.2021.105352

APA

Cherki, B. R., Winter, E., Mankuta, D., & Israel, S. (2021). Intranasal oxytocin, testosterone reactivity, and human competitiveness. Psychoneuroendocrinology, 132, Article 105352. https://doi.org/10.1016/j.psyneuen.2021.105352

Vancouver

Cherki BR, Winter E, Mankuta D, Israel S. Intranasal oxytocin, testosterone reactivity, and human competitiveness. Psychoneuroendocrinology. 2021 Oct 31;132:105352. Epub 2021 Jul 9. doi: 10.1016/j.psyneuen.2021.105352

Author

Cherki, B.R. ; Winter, E. ; Mankuta, D. et al. / Intranasal oxytocin, testosterone reactivity, and human competitiveness. In: Psychoneuroendocrinology. 2021 ; Vol. 132.

Bibtex

@article{468b3186b38d4d93aef2544b722afae5,
title = "Intranasal oxytocin, testosterone reactivity, and human competitiveness",
abstract = "Competitiveness is an essential feature of human social interactions. Despite an extensive body of research on the underlying psychological and cultural factors regulating competitive behavior, the role of biological factors remains poorly understood. Extant research has focused primarily on sex hormones, with equivocal findings. Here, we examined if intranasal administration of the neuropeptide oxytocin (OT) – a key regulator of human social behavior and cognition – interacts with changes in endogenous testosterone (T) levels in regulating the willingness to engage in competition. In a double-blind placebo-control design, 204 subjects (102 females) self-administrated OT or placebo and were assessed for their willingness to compete via an extensively-validated economic laboratory competition paradigm, in which, before completing a set of incentivized arithmetic tasks, subjects are asked to decide what percentage of their payoffs will be based on tournament paying-scheme. Salivary T concentrations (n = 197) were measured throughout the task to assess endogenous reactivity. Under both OT and placebo, T-reactivity during competition was not associated with competitiveness in females. However, in males, the association between T-reactivity and competitiveness was OT-dependent. That is, males under placebo demonstrated a positive correlation between T-reactivity and the willingness to engage in competition, while no association was observed in males receiving OT. The interaction between OT, T-reactivity, and sex on competitive preferences remained significant even after controlling for potential mediators such as performance, self-confidence, and risk-aversion, suggesting that this three-way interaction effect was specific to competitive motivation rather than to other generalized processes. These findings deepen our understanding of the biological processes underlying human preferences for competition and extend the evidence base for the interplay between hormones in affecting human social behavior. ",
keywords = "Competitiveness, Neurohormones, Oxytocin, Sex differences, Testosterone reactivity",
author = "B.R. Cherki and E. Winter and D. Mankuta and S. Israel",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Psychoneuroendocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychoneuroendocrinology, 132, 2021 DOI: 10.1016/j.psyneuen.2021.105352",
year = "2021",
month = oct,
day = "31",
doi = "10.1016/j.psyneuen.2021.105352",
language = "English",
volume = "132",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Intranasal oxytocin, testosterone reactivity, and human competitiveness

AU - Cherki, B.R.

AU - Winter, E.

AU - Mankuta, D.

AU - Israel, S.

N1 - This is the author’s version of a work that was accepted for publication in Psychoneuroendocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychoneuroendocrinology, 132, 2021 DOI: 10.1016/j.psyneuen.2021.105352

PY - 2021/10/31

Y1 - 2021/10/31

N2 - Competitiveness is an essential feature of human social interactions. Despite an extensive body of research on the underlying psychological and cultural factors regulating competitive behavior, the role of biological factors remains poorly understood. Extant research has focused primarily on sex hormones, with equivocal findings. Here, we examined if intranasal administration of the neuropeptide oxytocin (OT) – a key regulator of human social behavior and cognition – interacts with changes in endogenous testosterone (T) levels in regulating the willingness to engage in competition. In a double-blind placebo-control design, 204 subjects (102 females) self-administrated OT or placebo and were assessed for their willingness to compete via an extensively-validated economic laboratory competition paradigm, in which, before completing a set of incentivized arithmetic tasks, subjects are asked to decide what percentage of their payoffs will be based on tournament paying-scheme. Salivary T concentrations (n = 197) were measured throughout the task to assess endogenous reactivity. Under both OT and placebo, T-reactivity during competition was not associated with competitiveness in females. However, in males, the association between T-reactivity and competitiveness was OT-dependent. That is, males under placebo demonstrated a positive correlation between T-reactivity and the willingness to engage in competition, while no association was observed in males receiving OT. The interaction between OT, T-reactivity, and sex on competitive preferences remained significant even after controlling for potential mediators such as performance, self-confidence, and risk-aversion, suggesting that this three-way interaction effect was specific to competitive motivation rather than to other generalized processes. These findings deepen our understanding of the biological processes underlying human preferences for competition and extend the evidence base for the interplay between hormones in affecting human social behavior.

AB - Competitiveness is an essential feature of human social interactions. Despite an extensive body of research on the underlying psychological and cultural factors regulating competitive behavior, the role of biological factors remains poorly understood. Extant research has focused primarily on sex hormones, with equivocal findings. Here, we examined if intranasal administration of the neuropeptide oxytocin (OT) – a key regulator of human social behavior and cognition – interacts with changes in endogenous testosterone (T) levels in regulating the willingness to engage in competition. In a double-blind placebo-control design, 204 subjects (102 females) self-administrated OT or placebo and were assessed for their willingness to compete via an extensively-validated economic laboratory competition paradigm, in which, before completing a set of incentivized arithmetic tasks, subjects are asked to decide what percentage of their payoffs will be based on tournament paying-scheme. Salivary T concentrations (n = 197) were measured throughout the task to assess endogenous reactivity. Under both OT and placebo, T-reactivity during competition was not associated with competitiveness in females. However, in males, the association between T-reactivity and competitiveness was OT-dependent. That is, males under placebo demonstrated a positive correlation between T-reactivity and the willingness to engage in competition, while no association was observed in males receiving OT. The interaction between OT, T-reactivity, and sex on competitive preferences remained significant even after controlling for potential mediators such as performance, self-confidence, and risk-aversion, suggesting that this three-way interaction effect was specific to competitive motivation rather than to other generalized processes. These findings deepen our understanding of the biological processes underlying human preferences for competition and extend the evidence base for the interplay between hormones in affecting human social behavior.

KW - Competitiveness

KW - Neurohormones

KW - Oxytocin

KW - Sex differences

KW - Testosterone reactivity

U2 - 10.1016/j.psyneuen.2021.105352

DO - 10.1016/j.psyneuen.2021.105352

M3 - Journal article

VL - 132

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

M1 - 105352

ER -