Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans. / Knight, Jo; Gardner, G. T.; Clark, A. J. et al.
In: Journal of Human Hypertension, Vol. 14, No. 6, 06.2000, p. 385-387.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans
AU - Knight, Jo
AU - Gardner, G. T.
AU - Clark, A. J.
AU - Caulfield, M. J.
PY - 2000/6
Y1 - 2000/6
N2 - Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of markers located on chromosome 17q to essential hypertension in African Caribbean hypertensive families. No support of linkage was found between the markers studied and hypertension, however only genes of a lamda sib value of less than 1.8 could be excluded.
AB - Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of markers located on chromosome 17q to essential hypertension in African Caribbean hypertensive families. No support of linkage was found between the markers studied and hypertension, however only genes of a lamda sib value of less than 1.8 could be excluded.
KW - Africa
KW - African Continental Ancestry Group
KW - Caribbean Region
KW - Chromosome Mapping
KW - Chromosomes, Human, Pair 17
KW - Cohort Studies
KW - Genetic Linkage
KW - Humans
KW - Hypertension
M3 - Journal article
C2 - 10878700
VL - 14
SP - 385
EP - 387
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
IS - 6
ER -