Research output: Contribution to Journal/Magazine › Journal article › peer-review
Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD. / Hill, VL; Passerini, N; Craig, DQM et al.
In: Journal of Thermal Analysis and Calorimetry, Vol. 54, No. 2, 1998, p. 673-685.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD
AU - Hill, VL
AU - Passerini, N
AU - Craig, DQM
AU - Vickers, M
AU - Anwar, J
AU - Feely, LC
PY - 1998
Y1 - 1998
N2 - Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.
AB - Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.
KW - DIFFERENTIAL SCANNING CALORIMETRY
KW - poly(d,l-lactide)
KW - TMDSC
KW - PXRD
KW - DRUGS
KW - RELEASE
KW - MODULATED DSC
KW - MORPHOLOGY
KW - progesterone
KW - SEM
KW - TEMPERATURE
U2 - 10.1023/A:1010167214806
DO - 10.1023/A:1010167214806
M3 - Journal article
VL - 54
SP - 673
EP - 685
JO - Journal of Thermal Analysis and Calorimetry
JF - Journal of Thermal Analysis and Calorimetry
SN - 1388-6150
IS - 2
ER -