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Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD. / Hill, VL; Passerini, N; Craig, DQM et al.

In: Journal of Thermal Analysis and Calorimetry, Vol. 54, No. 2, 1998, p. 673-685.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hill, VL, Passerini, N, Craig, DQM, Vickers, M, Anwar, J & Feely, LC 1998, 'Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD', Journal of Thermal Analysis and Calorimetry, vol. 54, no. 2, pp. 673-685. https://doi.org/10.1023/A:1010167214806

APA

Hill, VL., Passerini, N., Craig, DQM., Vickers, M., Anwar, J., & Feely, LC. (1998). Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD. Journal of Thermal Analysis and Calorimetry, 54(2), 673-685. https://doi.org/10.1023/A:1010167214806

Vancouver

Hill VL, Passerini N, Craig DQM, Vickers M, Anwar J, Feely LC. Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD. Journal of Thermal Analysis and Calorimetry. 1998;54(2):673-685. doi: 10.1023/A:1010167214806

Author

Hill, VL ; Passerini, N ; Craig, DQM et al. / Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD. In: Journal of Thermal Analysis and Calorimetry. 1998 ; Vol. 54, No. 2. pp. 673-685.

Bibtex

@article{d65716b4c83b4a01a5f142c5320a4038,
title = "Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD",
abstract = "Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.",
keywords = "DIFFERENTIAL SCANNING CALORIMETRY, poly(d,l-lactide), TMDSC, PXRD, DRUGS, RELEASE, MODULATED DSC, MORPHOLOGY, progesterone, SEM, TEMPERATURE",
author = "VL Hill and N Passerini and DQM Craig and M Vickers and J Anwar and LC Feely",
year = "1998",
doi = "10.1023/A:1010167214806",
language = "English",
volume = "54",
pages = "673--685",
journal = "Journal of Thermal Analysis and Calorimetry",
issn = "1388-6150",
publisher = "Springer Netherlands",
number = "2",

}

RIS

TY - JOUR

T1 - Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD

AU - Hill, VL

AU - Passerini, N

AU - Craig, DQM

AU - Vickers, M

AU - Anwar, J

AU - Feely, LC

PY - 1998

Y1 - 1998

N2 - Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.

AB - Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.

KW - DIFFERENTIAL SCANNING CALORIMETRY

KW - poly(d,l-lactide)

KW - TMDSC

KW - PXRD

KW - DRUGS

KW - RELEASE

KW - MODULATED DSC

KW - MORPHOLOGY

KW - progesterone

KW - SEM

KW - TEMPERATURE

U2 - 10.1023/A:1010167214806

DO - 10.1023/A:1010167214806

M3 - Journal article

VL - 54

SP - 673

EP - 685

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

IS - 2

ER -