Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Isopropyl myristate-modified polyether-urethane coatings as protective barriers for implantable medical devices
AU - Roohpour, N.
AU - Wasikiewicz, J.M.
AU - Moshaverinia, A.
AU - Paul, D.
AU - Rehman, I.U.
AU - Vadgama, P.
PY - 2009
Y1 - 2009
N2 - Polyurethane films have potential applications in medicine, especially for packaging implantable medical devices. Although polyether-urethanes have superior mechanical properties and are biocompatible, achieving water resistance is still a challenge. Polyether based polyurethanes with two different molecular weights (PTMO1000, PTMO2000) were prepared from 4,4'-diphenylmethane diisocyanate and poly(tetra-methylene oxide). Polymer films were introduced using different concentrations (0.5-10 wt %) of isopropyl myristate lipid (IPM) as a non-toxic modifying agent. The physical and mechanical properties of these polymers were characterised using physical and spectroscopy techniques (FTIR, Raman, DSC, DMA, tensile testing). Water contact angle and water uptake of the membranes as a function of IPM concentration was also determined accordingly. The FTIR and Raman data indicate that IPM is dispersed in polyurethane at ≤ 2wt% and thermal analysis confirmed this miscibility to be dependent on soft segment length. Modified polymers showed increased tensile strength and failure strain as well as reduced water uptake by up to 24% at 1-2 wt% IPM. © 2009 by the authors.
AB - Polyurethane films have potential applications in medicine, especially for packaging implantable medical devices. Although polyether-urethanes have superior mechanical properties and are biocompatible, achieving water resistance is still a challenge. Polyether based polyurethanes with two different molecular weights (PTMO1000, PTMO2000) were prepared from 4,4'-diphenylmethane diisocyanate and poly(tetra-methylene oxide). Polymer films were introduced using different concentrations (0.5-10 wt %) of isopropyl myristate lipid (IPM) as a non-toxic modifying agent. The physical and mechanical properties of these polymers were characterised using physical and spectroscopy techniques (FTIR, Raman, DSC, DMA, tensile testing). Water contact angle and water uptake of the membranes as a function of IPM concentration was also determined accordingly. The FTIR and Raman data indicate that IPM is dispersed in polyurethane at ≤ 2wt% and thermal analysis confirmed this miscibility to be dependent on soft segment length. Modified polymers showed increased tensile strength and failure strain as well as reduced water uptake by up to 24% at 1-2 wt% IPM. © 2009 by the authors.
KW - Blend
KW - Isopropyl myristate
KW - Physical properties
KW - Polyether-urethane
KW - Diphenylmethane diisocyanate
KW - Implantable medical devices
KW - Physical and mechanical properties
KW - Polyether urethanes
KW - Polyurethane films
KW - Protective barrier
KW - Water contact angle
KW - Biocompatibility
KW - Blending
KW - Esters
KW - Ethers
KW - Fourier transform infrared spectroscopy
KW - Mechanical properties
KW - Polymer films
KW - Polymers
KW - Polyurethanes
KW - Tensile strength
KW - Tensile testing
KW - Thermoanalysis
KW - Biomedical equipment
U2 - 10.3390/ma2030719
DO - 10.3390/ma2030719
M3 - Journal article
VL - 2
SP - 719
EP - 733
JO - Materials
JF - Materials
SN - 1996-1944
IS - 3
ER -