Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Isotopic labelling in the study of organic and organometallic mechanism and structure: an account
AU - Lloyd-Jones, Guy C.
AU - Munoz-Herranz, Maria
PY - 2007/10/1
Y1 - 2007/10/1
N2 - An account of the use of stable isotopes (2H, 13C, 15N, 18O, 34S) for the study of organic and organometallic reaction mechanism and structure, by way of kinetic determinations and modelling, NMR spectroscopy and mass spectrometry is presented. The techniques discussed include use of kinetic isotope effects, label-facilitated nOe experiments, cross-over experiments, stereoisotopochemical analysis, label-facilitated NMR analysis of enantiomers using chiral-shift reagents and NMR in chiral liquid crystal matrices. The reactions in which these tools have been applied are ß-H elimination in Pd-s-alkyl complexes, the Bayliss–Hilman reaction, C–H insertion of stable carbenes, ring-closing metathesis reactions, palladium-catalysed hydrosilyation, palladium-catalysed cycloisomerization, anionic thia-Fries rearrangements, synthesis of proton sponges and their nitrogen stereodynamics, and transition metal (Pd, Mo) catalysed allylic alkylation
AB - An account of the use of stable isotopes (2H, 13C, 15N, 18O, 34S) for the study of organic and organometallic reaction mechanism and structure, by way of kinetic determinations and modelling, NMR spectroscopy and mass spectrometry is presented. The techniques discussed include use of kinetic isotope effects, label-facilitated nOe experiments, cross-over experiments, stereoisotopochemical analysis, label-facilitated NMR analysis of enantiomers using chiral-shift reagents and NMR in chiral liquid crystal matrices. The reactions in which these tools have been applied are ß-H elimination in Pd-s-alkyl complexes, the Bayliss–Hilman reaction, C–H insertion of stable carbenes, ring-closing metathesis reactions, palladium-catalysed hydrosilyation, palladium-catalysed cycloisomerization, anionic thia-Fries rearrangements, synthesis of proton sponges and their nitrogen stereodynamics, and transition metal (Pd, Mo) catalysed allylic alkylation
U2 - 10.1002/jlcr.1382
DO - 10.1002/jlcr.1382
M3 - Journal article
VL - 50
SP - 1072
EP - 1087
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 11-12
ER -