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    Rights statement: http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 129 (4), pp 339-409 2004, © 2004 Cambridge University Press.

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Leishmania donovani is the only cause of visceral leishmaniasis in East Africa; previous descriptions of L. infantum and "L. archibaldi" from this region are a consequence of convergent evolution in the isoenzyme data

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Leishmania donovani is the only cause of visceral leishmaniasis in East Africa; previous descriptions of L. infantum and "L. archibaldi" from this region are a consequence of convergent evolution in the isoenzyme data. / Jamjoom, M B; Ashford, R W; Bates, P A et al.
In: Parasitology, Vol. 129, No. 4, 10.2004, p. 399-409.

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@article{9303baa74c024a72b2a4ad5ecbdf83be,
title = "Leishmania donovani is the only cause of visceral leishmaniasis in East Africa; previous descriptions of L. infantum and {"}L. archibaldi{"} from this region are a consequence of convergent evolution in the isoenzyme data",
abstract = "Isoenzyme-based studies have identified 3 taxa/species/'phylogenetic complexes' as agents of visceral leishmaniasis in Sudan: L. donovani, L. infantum and {"}L. archibaldi{"}. However, these observations remain controversial. A new chitinase gene phylogeny was constructed in which stocks of all 3 putative species isolated in Sudan formed a monophyletic clade. In order to construct a more robust classification of the L. donovani complex, a panel of 16 microsatellite markers was used to describe 39 stocks of these 3 species. All {"}L. donovani complex{"} stocks from Sudan were again found to form a single monophyletic clade. L. donovani ss stocks from India and Kenya were found to form 2 region-specific clades. The partial sequence of the glutamate oxaloacetate transaminase (GOT) gene of 17 L. donovani complex stocks was obtained. A single nucleotide polymorphism in the GOT gene appeared to underlie the isoenzyme classification. It was concluded that isoenzyme-based identification is unsafe for stocks isolated in L. donovani endemic areas and identified as L. infantum. It was also concluded that the name L. archibaldi is invalid and that only a single visceralizing species, Leishmania donovani, is found in East Africa.",
keywords = "aspartate aminotransferase, microsatellites , MLEE , kala azar , Ethiopia , chagasi",
author = "Jamjoom, {M B} and Ashford, {R W} and Bates, {P A} and Chance, {M L} and Kemp, {S J} and Watts, {P C} and Noyes, {H A}",
note = "http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 129 (4), pp 339-409 2004, {\textcopyright} 2004 Cambridge University Press.",
year = "2004",
month = oct,
doi = "10.1017/S0031182004005955",
language = "English",
volume = "129",
pages = "399--409",
journal = "Parasitology",
issn = "0031-1820",
publisher = "Cambridge University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Leishmania donovani is the only cause of visceral leishmaniasis in East Africa; previous descriptions of L. infantum and "L. archibaldi" from this region are a consequence of convergent evolution in the isoenzyme data

AU - Jamjoom, M B

AU - Ashford, R W

AU - Bates, P A

AU - Chance, M L

AU - Kemp, S J

AU - Watts, P C

AU - Noyes, H A

N1 - http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 129 (4), pp 339-409 2004, © 2004 Cambridge University Press.

PY - 2004/10

Y1 - 2004/10

N2 - Isoenzyme-based studies have identified 3 taxa/species/'phylogenetic complexes' as agents of visceral leishmaniasis in Sudan: L. donovani, L. infantum and "L. archibaldi". However, these observations remain controversial. A new chitinase gene phylogeny was constructed in which stocks of all 3 putative species isolated in Sudan formed a monophyletic clade. In order to construct a more robust classification of the L. donovani complex, a panel of 16 microsatellite markers was used to describe 39 stocks of these 3 species. All "L. donovani complex" stocks from Sudan were again found to form a single monophyletic clade. L. donovani ss stocks from India and Kenya were found to form 2 region-specific clades. The partial sequence of the glutamate oxaloacetate transaminase (GOT) gene of 17 L. donovani complex stocks was obtained. A single nucleotide polymorphism in the GOT gene appeared to underlie the isoenzyme classification. It was concluded that isoenzyme-based identification is unsafe for stocks isolated in L. donovani endemic areas and identified as L. infantum. It was also concluded that the name L. archibaldi is invalid and that only a single visceralizing species, Leishmania donovani, is found in East Africa.

AB - Isoenzyme-based studies have identified 3 taxa/species/'phylogenetic complexes' as agents of visceral leishmaniasis in Sudan: L. donovani, L. infantum and "L. archibaldi". However, these observations remain controversial. A new chitinase gene phylogeny was constructed in which stocks of all 3 putative species isolated in Sudan formed a monophyletic clade. In order to construct a more robust classification of the L. donovani complex, a panel of 16 microsatellite markers was used to describe 39 stocks of these 3 species. All "L. donovani complex" stocks from Sudan were again found to form a single monophyletic clade. L. donovani ss stocks from India and Kenya were found to form 2 region-specific clades. The partial sequence of the glutamate oxaloacetate transaminase (GOT) gene of 17 L. donovani complex stocks was obtained. A single nucleotide polymorphism in the GOT gene appeared to underlie the isoenzyme classification. It was concluded that isoenzyme-based identification is unsafe for stocks isolated in L. donovani endemic areas and identified as L. infantum. It was also concluded that the name L. archibaldi is invalid and that only a single visceralizing species, Leishmania donovani, is found in East Africa.

KW - aspartate aminotransferase

KW - microsatellites

KW - MLEE

KW - kala azar

KW - Ethiopia

KW - chagasi

U2 - 10.1017/S0031182004005955

DO - 10.1017/S0031182004005955

M3 - Journal article

C2 - 15521628

VL - 129

SP - 399

EP - 409

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 4

ER -