Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

Biomedical and Life Sciences

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https://doi.org/10.1016/j.micinf.2010.05.014
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Keywords

Animals, Disease Vectors, Female, Insect Bites and Stings, Leishmania infantum, Leishmaniasis, Cutaneous, Membrane Proteins, Mice, Mice, Inbred BALB C, Proteoglycans, Protozoan Proteins, Psychodidae, Regurgitation, Gastric, Skin

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Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues. / Rogers, Matthew Edward; Corware, Karina; Müller, Ingrid et al.
In: Microbes and Infection, Vol. 12, No. 11, 10.2010, p. 875-879.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{e50eb1b4cce243abb615ac412e8d7d7f,

title = "Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues",

abstract = "We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L. infantum metacyclic promastigotes per infected bite. Using both low (10³) and high (10⁵) doses of parasites in the ears of BALB/c mice we show that the infections benefit from the presence of vector saliva and parasite gel in the skin. However, chronic infection of the spleen was only enhanced in high dose co-infections with gel. These results provide the framework for a more natural experimental model of visceral leishmaniasis.",

keywords = "Animals, Disease Vectors, Female, Insect Bites and Stings, Leishmania infantum, Leishmaniasis, Cutaneous, Membrane Proteins, Mice, Mice, Inbred BALB C, Proteoglycans, Protozoan Proteins, Psychodidae, Regurgitation, Gastric, Skin",

author = "Rogers, {Matthew Edward} and Karina Corware and Ingrid M{\"u}ller and Bates, {Paul Andrew}",

note = "Copyright {\textcopyright} 2010. Published by Elsevier SAS.",

year = "2010",

month = oct,

doi = "10.1016/j.micinf.2010.05.014",

language = "English",

volume = "12",

pages = "875--879",

journal = "Microbes and Infection",

issn = "1769-714X",

publisher = "Elsevier Masson SAS",

number = "11",

}

RIS

TY - JOUR

T1 - Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

AU - Rogers, Matthew Edward

AU - Corware, Karina

AU - Müller, Ingrid

AU - Bates, Paul Andrew

PY - 2010/10

Y1 - 2010/10

N2 - We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L. infantum metacyclic promastigotes per infected bite. Using both low (10³) and high (10⁵) doses of parasites in the ears of BALB/c mice we show that the infections benefit from the presence of vector saliva and parasite gel in the skin. However, chronic infection of the spleen was only enhanced in high dose co-infections with gel. These results provide the framework for a more natural experimental model of visceral leishmaniasis.

AB - We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L. infantum metacyclic promastigotes per infected bite. Using both low (10³) and high (10⁵) doses of parasites in the ears of BALB/c mice we show that the infections benefit from the presence of vector saliva and parasite gel in the skin. However, chronic infection of the spleen was only enhanced in high dose co-infections with gel. These results provide the framework for a more natural experimental model of visceral leishmaniasis.

KW - Animals

KW - Disease Vectors

KW - Female

KW - Insect Bites and Stings

KW - Leishmania infantum

KW - Leishmaniasis, Cutaneous

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred BALB C

KW - Proteoglycans

KW - Protozoan Proteins

KW - Psychodidae

KW - Regurgitation, Gastric

KW - Skin

U2 - 10.1016/j.micinf.2010.05.014

DO - 10.1016/j.micinf.2010.05.014

M3 - Journal article

C2 - 20561596

VL - 12

SP - 875

EP - 879

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1769-714X

IS - 11

ER -

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