TY - JOUR

T1 - Liquid-liquid phase equilibria of aqueous biphasic systems based on glycerol formal

T2 - Application on tetracycline recovery from water

AU - Praikaew, W.

AU - Kiatkittipong, W.

AU - Kiatkittipong, K.

AU - Assabumrungrat, S.

AU - Aiouache, F.

AU - Najdanovic-Visak, V.

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Chemical and Engineering Data, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.jced.9b00376

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Biopharmaceuticals are commonly present in relatively low concentrations in aqueous solutions, making their detection and purification detrimental. In this work, we used novel aqueous biphasic systems based on glycerol formal (GF) to extract an important antibiotic - tetracycline. We report cloud points (solubility curve) and tie-lines for three ternary systems, containing GF, water, and inorganic salt (either K 3PO 4, K 2HPO 4, or K 2CO 3) at constant temperature of 298 K and at 0.1 MPa. The tie-line data of these ternary systems were correlated using the nonrandom two-liquid model, and binary interaction parameters of activity coefficients were estimated. The experimental and correlated tie-line data were compared in terms of average root-mean-square deviation and showed satisfactory agreements. The partition coefficients of tetracycline between two phases were measured, and corresponding extraction efficiencies were calculated. The maximum value of partition coefficient was 1551 for the system containing K 3PO 4, followed by values of 1145 and 927 for systems containing K 2CO 3 and K 2HPO 4, respectively. The calculated extraction efficiencies were very high - greater than 98.8%, demonstrating high potential for using aqueous biphasic systems based on GF for separation and purification processes.

AB - Biopharmaceuticals are commonly present in relatively low concentrations in aqueous solutions, making their detection and purification detrimental. In this work, we used novel aqueous biphasic systems based on glycerol formal (GF) to extract an important antibiotic - tetracycline. We report cloud points (solubility curve) and tie-lines for three ternary systems, containing GF, water, and inorganic salt (either K 3PO 4, K 2HPO 4, or K 2CO 3) at constant temperature of 298 K and at 0.1 MPa. The tie-line data of these ternary systems were correlated using the nonrandom two-liquid model, and binary interaction parameters of activity coefficients were estimated. The experimental and correlated tie-line data were compared in terms of average root-mean-square deviation and showed satisfactory agreements. The partition coefficients of tetracycline between two phases were measured, and corresponding extraction efficiencies were calculated. The maximum value of partition coefficient was 1551 for the system containing K 3PO 4, followed by values of 1145 and 927 for systems containing K 2CO 3 and K 2HPO 4, respectively. The calculated extraction efficiencies were very high - greater than 98.8%, demonstrating high potential for using aqueous biphasic systems based on GF for separation and purification processes.

KW - Efficiency

KW - Glycerol

KW - Liquids

KW - Phase equilibria

KW - Potash

KW - Purification

KW - Solvent extraction

KW - Aqueous biphasic system

KW - Binary interaction parameter

KW - Extraction efficiencies

KW - Liquid-liquid phase equilibria

KW - Nonrandom two-liquid model

KW - Partition coefficient

KW - Root mean square deviations

KW - Separation and purification

KW - Ternary systems

U2 - 10.1021/acs.jced.9b00376

DO - 10.1021/acs.jced.9b00376

M3 - Journal article

VL - 64

SP - 4856

EP - 4862

JO - Journal of Chemical and Engineering Data

JF - Journal of Chemical and Engineering Data

SN - 0021-9568

IS - 11

ER -