Localization and possible role of membrane type metalloproteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation

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https://doi.org/10.1007/BF02898893
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Keywords

placenta, trophoblast, basal plate, fetal membrane, MT-1-MMP, TIMP-1, in situ hybridization, PLASMINOGEN-ACTIVATOR, MATRIX, EXPRESSION, MECHANISMS, PREGNANCY, MT1-MMP, SURFACE, MMP-2, CELLS

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Localization and possible role of membrane type metalloproteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation. / Liu, Y X ; Hu, Z Y ; Feng, Q et al.
In: Chinese Science Bulletin, Vol. 45, No. 16, 08.2000, p. 1484-1489.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{319f997a843b44ffa6a17267bf04b079,

title = "Localization and possible role of membrane type metalloproteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation",

abstract = "Human placental tissues from the first and second trimesters of gestation have been investigated using riboprobe in situ hybridisation of mRNA sequences coding for membrane type metalloproteinase (MT-1-MMP) and tissue inhibitors of metalloproteinase-l (TIMP-1). Results show that (i) both mRNAs express at a relatively high level in the chorion laeve trophoblast cells and the adjacent decidual cells of fetal membrane; (ii) the most abundant expression of the two mRNAs was found in the extravillous trophoblast between Rohrs and Nitabuch striae of basal plate, trophoblast shell and gland cells of the decidua; (iii) isolated or small groups of cytotrophoblast cells in the chorionic villi and in the cells lining arterioles in decidua and stem villi also expressed both MT-1-MMP and TIMP-1 at defferent extents. The data suggest that the coordinated expression of the MT-MMP and its inhibitor TIMP in defferent cells of the placental tissue may play an essential role in trophoblast invasion and angiogenesis related to placentation in the first two trimesters of gestation. They may also have an ability to effect separation of fetal from material tissue at a favorable junctional site during parturition.",

keywords = "placenta, trophoblast, basal plate, fetal membrane, MT-1-MMP, TIMP-1, in situ hybridization, PLASMINOGEN-ACTIVATOR, MATRIX, EXPRESSION, MECHANISMS, PREGNANCY, MT1-MMP, SURFACE, MMP-2, CELLS",

author = "Liu, {Y X} and Hu, {Z Y} and Q Feng and Gao, {H J} and K Liu and Ockleford, {C D}",

year = "2000",

month = aug,

doi = "10.1007/BF02898893",

language = "English",

volume = "45",

pages = "1484--1489",

journal = "Chinese Science Bulletin",

issn = "1001-6538",

publisher = "Science in China Press",

number = "16",

}

RIS

TY - JOUR

T1 - Localization and possible role of membrane type metalloproteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation

AU - Liu, Y X

AU - Hu, Z Y

AU - Feng, Q

AU - Gao, H J

AU - Liu, K

AU - Ockleford, C D

PY - 2000/8

Y1 - 2000/8

N2 - Human placental tissues from the first and second trimesters of gestation have been investigated using riboprobe in situ hybridisation of mRNA sequences coding for membrane type metalloproteinase (MT-1-MMP) and tissue inhibitors of metalloproteinase-l (TIMP-1). Results show that (i) both mRNAs express at a relatively high level in the chorion laeve trophoblast cells and the adjacent decidual cells of fetal membrane; (ii) the most abundant expression of the two mRNAs was found in the extravillous trophoblast between Rohrs and Nitabuch striae of basal plate, trophoblast shell and gland cells of the decidua; (iii) isolated or small groups of cytotrophoblast cells in the chorionic villi and in the cells lining arterioles in decidua and stem villi also expressed both MT-1-MMP and TIMP-1 at defferent extents. The data suggest that the coordinated expression of the MT-MMP and its inhibitor TIMP in defferent cells of the placental tissue may play an essential role in trophoblast invasion and angiogenesis related to placentation in the first two trimesters of gestation. They may also have an ability to effect separation of fetal from material tissue at a favorable junctional site during parturition.

AB - Human placental tissues from the first and second trimesters of gestation have been investigated using riboprobe in situ hybridisation of mRNA sequences coding for membrane type metalloproteinase (MT-1-MMP) and tissue inhibitors of metalloproteinase-l (TIMP-1). Results show that (i) both mRNAs express at a relatively high level in the chorion laeve trophoblast cells and the adjacent decidual cells of fetal membrane; (ii) the most abundant expression of the two mRNAs was found in the extravillous trophoblast between Rohrs and Nitabuch striae of basal plate, trophoblast shell and gland cells of the decidua; (iii) isolated or small groups of cytotrophoblast cells in the chorionic villi and in the cells lining arterioles in decidua and stem villi also expressed both MT-1-MMP and TIMP-1 at defferent extents. The data suggest that the coordinated expression of the MT-MMP and its inhibitor TIMP in defferent cells of the placental tissue may play an essential role in trophoblast invasion and angiogenesis related to placentation in the first two trimesters of gestation. They may also have an ability to effect separation of fetal from material tissue at a favorable junctional site during parturition.

KW - placenta

KW - trophoblast

KW - basal plate

KW - fetal membrane

KW - MT-1-MMP

KW - TIMP-1

KW - in situ hybridization

KW - PLASMINOGEN-ACTIVATOR

KW - MATRIX

KW - EXPRESSION

KW - MECHANISMS

KW - PREGNANCY

KW - MT1-MMP

KW - SURFACE

KW - MMP-2

KW - CELLS

U2 - 10.1007/BF02898893

DO - 10.1007/BF02898893

M3 - Journal article

VL - 45

SP - 1484

EP - 1489

JO - Chinese Science Bulletin

JF - Chinese Science Bulletin

SN - 1001-6538

IS - 16

ER -

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